Controlled, cross-sectional MRI evaluation of joint status in severe haemophilia A patients treated with prophylaxis vs. on demand
- Oldenburg, J.
- Zimmermann, R.
- Katsarou, O.
- Theodossiades, G.
- Zanon, E.
- Niemann, B.
- Kellermann, E.
- Lundin, Björn
DOIAbstract
In patients with haemophilia A, factor VIII (FVIII) prophylaxis reduces bleeding frequency and joint damage compared with on-demand therapy. To assess the effect of prophylaxis initiation age, magnetic resonance imaging (MRI) was used to evaluate bone and cartilage damage in patients with severe haemophilia A. In this cross-sectional, multinational investigation, patients aged 12-35years were assigned to 1 of 5 groups: primary prophylaxis started at age <2years (group 1); secondary prophylaxis started at age 2 to <6years (group 2), 6 to <12years (group 3), or 12-18years (group 4); or on-demand treatment (group 5). Joint status at ankles and knees was assessed using Compatible Additive MRI scoring (maximum and mean ankle; maximum and mean of...
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