Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases
- Bretillon, L
- Siden, A
- Wahlund, L O
- Lutjohann, D
- Minthon, Lennart
- Crisby, M
- Hillert, J
- Groth, C G
- Diczfalusy, U
- Bjorkhem, I
DOIAbstract
The brain is the exclusive or almost exclusive site of formation of 24S-hydroxycholesterol and we have shown that the circulating level of 24S-hydroxycholesterol is dependent upon the relation between cerebral production and hepatic clearance. In the present work we determined plasma levels of 24S-hydroxycholesterol in patients with various neurological diseases. Eleven subjects with brain death occurring 6-10 h before collection of the plasma samples had markedly reduced circulating levels of 24S-hydroxycholesterol (-43%, P<0.001). Patients with advanced Alzheimer's disease and cerebral inflammatory diseases had slightly lower levels of 24S-hydroxycholesterol in plasma when compared to matched controls. Patients with acute ischemic stroke,...
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