Background & Aims: Three pathways control gastric acid secretion: the gastrin-enterochromaffin-like (ECL) cell axis, the vagus-parietal cell axis, and the cholecystokinin (CCK)-D cell axis. Mice lacking gastrin or both gastrin and CCK were examined to determine the role of the hormones. Methods: Acid was measured after pylorus ligation, and biopsies from gastrin knockout (KO), gastrin-CCK double-KO, and wild-type (WT) mice were collected for biochemical, immunocytochemical, and electron-microscopic examination. Results: The ECL cells were inactive in both groups of mutant mice but the cell number was unaffected. Both parietal cell number and level of H+/K+-ATPase messenger RNA (mRNA) were reduced in the mutant strains, but gastrin-CCK doubl...
AbstractGastric acid secretion is mediated by the H/K-ATPase of parietal cells. Activation of acid s...
The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, p...
We developed a unique virtual human model of gastric acid secretion and its regulation in which food...
The primary objective of this research was to investigate the roles of gastrin and histamine in the ...
Gastrin, released from antral G-cells, plays an important role in the regulation of gastric acid sec...
Mice that lack the ability to produce gastrin (Gas-KO) are unable to secrete .gastric acid in respon...
The antral hormone gastrin and its intestinal relative, cholecystokinin (CCK), are pivotal in the re...
Helicobacter pylori infection is a causal factor of gastric cancer (which is associated with low gas...
The duodenal mucosa protects itself from gastric acid injury by the secretion of bicarbonate. We det...
Background & Aims: Gastrin deficiency and proton pump inhibitor treatment cause achlorhydria, which ...
tric acid secretion is mediated by M3 and M5 but not M1 muscarinic acetylcholine receptors in mice. ...
Constitutive cyclooxygenase-1 enzyme synthesizes prostaglandins which are thought to play an importa...
The antral hormone gastrin is the key regulator of gastric acid secretion, mucosal growth and differ...
Utilizing genetically deficient mice, I tested the hypothesis that cholecystokinin (CCK) is required...
The present studies were designed to examine the effects of ClC-2 ablation on cellular mor-phology, ...
AbstractGastric acid secretion is mediated by the H/K-ATPase of parietal cells. Activation of acid s...
The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, p...
We developed a unique virtual human model of gastric acid secretion and its regulation in which food...
The primary objective of this research was to investigate the roles of gastrin and histamine in the ...
Gastrin, released from antral G-cells, plays an important role in the regulation of gastric acid sec...
Mice that lack the ability to produce gastrin (Gas-KO) are unable to secrete .gastric acid in respon...
The antral hormone gastrin and its intestinal relative, cholecystokinin (CCK), are pivotal in the re...
Helicobacter pylori infection is a causal factor of gastric cancer (which is associated with low gas...
The duodenal mucosa protects itself from gastric acid injury by the secretion of bicarbonate. We det...
Background & Aims: Gastrin deficiency and proton pump inhibitor treatment cause achlorhydria, which ...
tric acid secretion is mediated by M3 and M5 but not M1 muscarinic acetylcholine receptors in mice. ...
Constitutive cyclooxygenase-1 enzyme synthesizes prostaglandins which are thought to play an importa...
The antral hormone gastrin is the key regulator of gastric acid secretion, mucosal growth and differ...
Utilizing genetically deficient mice, I tested the hypothesis that cholecystokinin (CCK) is required...
The present studies were designed to examine the effects of ClC-2 ablation on cellular mor-phology, ...
AbstractGastric acid secretion is mediated by the H/K-ATPase of parietal cells. Activation of acid s...
The present studies were designed to examine the effects of ClC-2 ablation on cellular morphology, p...
We developed a unique virtual human model of gastric acid secretion and its regulation in which food...