Development of and Recovery from Secondary Hypogonadism in Aging Men: Prospective Results from the EMAS
- Rastrelli, Giulia
- Carter, Emma L.
- Ahern, Tomas
- Finn, Joseph D.
- Antonio, Leen
- O'Neill, Terence W.
- Bartfai, Gyorgy
- Casanueva, Felipe F.
- Forti, Gianni
- Keevil, Brian
- Maggi, Mario
- Giwercman, Aleksander
- Han, Thang S.
- Huhtaniemi, Ilpo T.
- Kula, Krzysztof
- Lean, Michael E. J.
- Pendleton, Neil
- Punab, Margus
- Vanderschueren, Dirk
- Wu, Frederick C. W.
DOIAbstract
Context: Secondary hypogonadism is common in aging men; its natural history and predisposing factors are unclear. Objectives: The objectives were 1) to identify factors that predispose eugonadal men (T >= 10.5 nmol/L) to develop biochemical secondary hypogonadism (T = 30 kg/m(2); odds ratio [OR] = 2.86 [95% confidenceinterval, 1.67; 4.90]; P = 102 cm, respectively). Incident secondary hypogonadal men experienced new/worsening sexual symptoms (low libido, erectile dysfunction, and infrequent spontaneous erections). Recovery from secondary hypogonadism was predicted by nonobesity(OR = 2.28 [1.21; 4.31]; P = .011), weight loss (OR = 2.24 [1.04; 4.85]; P = .042), normal waist circumference (OR = 1.93 [1.01; 3.70]; P = .048), younger age (<60 y;...
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