Add to ORKGHigh-grade gliomas are one of the most aggressive human tumors with <1% of patients surviving 5 years after surgery. Immunotherapy could offer a possibility to eradicate remnant tumor cells after conventional therapy. Experimental immunotherapy can induce partial cure of established intracerebral tumors in several rodent models. One reason for the limited therapeutic effects could be immunosuppression induced by both the growing tumor and the induced immune reaction. NO has been implicated in tumor-derived immune suppression in tumor-bearing hosts, and unspecific inhibitors of NO synthase have been shown to boost antitumor immunity. In this study, we show that the inducible NO synthase (iNOS)-specific inhibitor mercaptoethylguanidine (MEG) ...
Progress in the definition of the roles of various costimulators and cytokines in determining the ty...
The hypothesis pertinent to this thesis is that glioma tumours can be therapeutically targeted by ge...
Microglia are the primary central nervous system immune effector cells. Microglial activation is lin...
During tumor progression a strong immunosuppression is developed and is believed to be the major rea...
This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growt...
Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucida...
Immunotherapy of malignant primary brain tumors holds the potential to improve the dismal prognosis ...
Immunotherapy of malignant primary brain tumors holds the potential to improve the dismal prognosis ...
Malignant brain tumors induce pronounced immunosuppression, which diminishes immune responses genera...
Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offe...
Nitric oxide synthases (NOS) are important mediators of pro-growth signaling in tumor cells, as they...
Immunotherapeutic strategies for glioblastoma, the most frequent malignant primary brain tumor, aim ...
Glioma treatments are faced with challenges, including the inability to fully eliminate cancer stem ...
Abstract Background Nitric oxide-releasing drugs are used for cardiovascular diseases; however, thei...
Glioblastoma multiforme is the most common and aggressive malignant brain tumor in humans, and the p...
Progress in the definition of the roles of various costimulators and cytokines in determining the ty...
The hypothesis pertinent to this thesis is that glioma tumours can be therapeutically targeted by ge...
Microglia are the primary central nervous system immune effector cells. Microglial activation is lin...
During tumor progression a strong immunosuppression is developed and is believed to be the major rea...
This study aims at clarifying the role of NO in the immunosuppression induced by in vivo tumor growt...
Nitric oxide (NO) can modulate both tumor growth and antitumor immune responses. In order to elucida...
Immunotherapy of malignant primary brain tumors holds the potential to improve the dismal prognosis ...
Immunotherapy of malignant primary brain tumors holds the potential to improve the dismal prognosis ...
Malignant brain tumors induce pronounced immunosuppression, which diminishes immune responses genera...
Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offe...
Nitric oxide synthases (NOS) are important mediators of pro-growth signaling in tumor cells, as they...
Immunotherapeutic strategies for glioblastoma, the most frequent malignant primary brain tumor, aim ...
Glioma treatments are faced with challenges, including the inability to fully eliminate cancer stem ...
Abstract Background Nitric oxide-releasing drugs are used for cardiovascular diseases; however, thei...
Glioblastoma multiforme is the most common and aggressive malignant brain tumor in humans, and the p...
Progress in the definition of the roles of various costimulators and cytokines in determining the ty...
The hypothesis pertinent to this thesis is that glioma tumours can be therapeutically targeted by ge...
Microglia are the primary central nervous system immune effector cells. Microglial activation is lin...