Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.
- Tada, Hayato
- Won, Hong-Hee
- Melander, Olle
- Yang, Jian
- Peloso, Gina M
- Kathiresan, Sekar
Publication date
January 2014
DOI Publisher
Ovid Technologies (Wolters Kluwer Health)Abstract
-Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD
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