Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies
- Key, T. J.
- Appleby, P. N.
- Reeves, G. K.
- Roddam, A. W.
- Helzlsouer, K. J.
- Alberg, A. J.
- Rollison, D. E.
- Dorgan, J. F.
- Brinton, L. A.
- Overvad, K.
- Kaaks, R.
- Trichopoulou, A.
- Clavel-Chapelon, F.
- Panico, S.
- Duell, E. J.
- Peeters, P. H. M.
- Rinaldi, S.
- Riboli, E.
- Fentiman, I. S.
- Dowsett, M.
- Manjer, Jonas
- Lenner, P.
- Hallmans, G.
- Baglietto, L.
- English, D. R.
- Giles, G. G.
- Hopper, J. L.
- Severi, G.
- Morris, H. A.
- Koenig, K.
- Zeleniuch-Jacquotte, A.
- Arslan, A. A.
- Toniolo, P.
- Shore, R. E.
- Krogh, V.
- Micheli, A.
- Berrino, F.
- Muti, P.
- Barrett-Connor, E.
- Laughlin, G. A.
- Kabuto, M.
- Akiba, S.
- Stevens, R. G.
- Neriishi, K.
- Land, C. E.
- Cauley, J. A.
- Lui, Li Yung
- Cummings, Steven R.
- Gunter, M. J.
- Rohan, T. E.
- Strickler, H. D.
DOIAbstract
BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free test...
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