Streptococcus pyogenes adheres to epithelial cells of the human pharynx where it can cause pharyngitis. To counteract infection. inflamed epithelium produces peptide antibiotics, among them the CXC chemokine MIG/CXCL9. M protein is both a surface-associated and released virulence factor of S. pyogenes. Here we show that soluble M1 protein enhances MIG gene expression and synthesis in IFN-gamma stimulated epithelial cells. M1 protein was recognized both by resting and IFN-gamma activated pharyngeal epithelial cells as detected by activation of the transcription factor NF-kappa B. Furthermore, pharmacological inhibition of NF-kappa B. decreased MIG synthesis in IFN-gamma activated cells, demonstrating a key role for NF-kappa B in mediating th...
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adul...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
Albumin (HSA) is the dominating protein in human plasma. Many bacterial species, especially streptoc...
Pharyngitis caused by Streptococcus pyogenes is one of the most common bacterial infections in human...
Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. S...
Group A Streptococcus (GAS) is a leading human pathogen producing a diverse array of infections from...
From an evolutionary point of view a pathogen might benefit from regulating the inflammatory respons...
From an evolutionary point of view a pathogen might benefit from regulating the inflammatory respons...
Streptococcus dysgalactiae subsp. equisimilis (group G streptococci; GGS) cause disease in humans bu...
Background: The group A Streptococcus (GAS) M1 protein binds fibrinogen (Fg) to block phagocytosis a...
MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-tr...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including li...
Group A streptococcus (GAS), a common pathogen, is able to escape host immune attack and thus surviv...
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adul...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
Albumin (HSA) is the dominating protein in human plasma. Many bacterial species, especially streptoc...
Pharyngitis caused by Streptococcus pyogenes is one of the most common bacterial infections in human...
Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. S...
Group A Streptococcus (GAS) is a leading human pathogen producing a diverse array of infections from...
From an evolutionary point of view a pathogen might benefit from regulating the inflammatory respons...
From an evolutionary point of view a pathogen might benefit from regulating the inflammatory respons...
Streptococcus dysgalactiae subsp. equisimilis (group G streptococci; GGS) cause disease in humans bu...
Background: The group A Streptococcus (GAS) M1 protein binds fibrinogen (Fg) to block phagocytosis a...
MIG/CXCL9 belongs to the CXC family of chemokines and participates in the regulation of leukocyte-tr...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including li...
Group A streptococcus (GAS), a common pathogen, is able to escape host immune attack and thus surviv...
Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and adul...
<p>Streptococcus pyogenes (Group A Streptococcus; GAS) commonly causes pharyngitis in children and a...
Albumin (HSA) is the dominating protein in human plasma. Many bacterial species, especially streptoc...