The apolipoprotein E (ApoE) epsilon 4 allele is the strongest risk factor of sporadic Alzheimer's disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2, ApoE3 and ApoE4) in AD patients and among APOE genotypes (APOE epsilon 2, epsilon 3, epsilon 4) remain controversial. Using a novel mass spectrometry-based method, we quantified total ApoE and specific ApoE isoform concentrations and potential associations with age, cognitive status, cholesterol levels and established AD biomarkers in cerebrospinal fluid (CSF) from AD patients versus non-AD individuals with different APOE genotypes. We also investigated plasma total ApoE and ApoE isoform composition in a subset of these individuals. In total n = 43 AD and...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provide...
The relationship between structural variants of the apolipoprotein E gene, APOE epsilon2/epsilon3/ep...
Background: Low levels of plasma apolipoprotein E (apoE) and presence of the APOE epsilon 4 allele a...
Background: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
Apolipoprotein E (APOE) ε4 allele is the most important genetic risk factor for Alzheimer's disease ...
AbstractA targeted mass spectrometric assay was developed for identification and quantification of a...
Objective: There is mounting evidence for the contribution of apoE to the pathophysiology of Alzheim...
BackgroundThe ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most impor...
BACKGROUND: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
Background. The presence of brain hyperphosphorylated tau constitutes a hallmark of neurodegenerativ...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
Apolipoprotein E4 (apoE4) has been identified as a major risk factor for Alzheimer disease (AD). Pre...
Aims of this study were to evaluate the influence of apolipoprotein E (apoE) genotype on serum apoE ...
Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarker...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provide...
The relationship between structural variants of the apolipoprotein E gene, APOE epsilon2/epsilon3/ep...
Background: Low levels of plasma apolipoprotein E (apoE) and presence of the APOE epsilon 4 allele a...
Background: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
Apolipoprotein E (APOE) ε4 allele is the most important genetic risk factor for Alzheimer's disease ...
AbstractA targeted mass spectrometric assay was developed for identification and quantification of a...
Objective: There is mounting evidence for the contribution of apoE to the pathophysiology of Alzheim...
BackgroundThe ε4 allele of apolipoprotein E (APOE) gene and increasing age are two of the most impor...
BACKGROUND: The human APOE gene, which codes for apolipoprotein E (apoE), has three major polymorphi...
Background. The presence of brain hyperphosphorylated tau constitutes a hallmark of neurodegenerativ...
Apolipoprotein E isoforms (apoE2, apoE3, and apoE4) affect the likelihood of developing Alzheimer’s ...
Apolipoprotein E4 (apoE4) has been identified as a major risk factor for Alzheimer disease (AD). Pre...
Aims of this study were to evaluate the influence of apolipoprotein E (apoE) genotype on serum apoE ...
Alzheimer’s disease (AD) is the most common form of dementia and cerebrospinal fluid (CSF) biomarker...
International audienceAllelic polymorphism of the apolipoprotein E (ApoE) gene (ApoE epsilon 2, ApoE...
Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provide...
The relationship between structural variants of the apolipoprotein E gene, APOE epsilon2/epsilon3/ep...