Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
- Horikawa, Y
- Oda, N
- Cox, N J
- Li, X
- Orho-Melander, Marju
- Hara, M
- Hinokio, Y
- Lindner, T H
- Mashima, H
- Schwarz, P E
- del Bosque-Plata, L
- Horikawa, Y
- Oda, Y
- Yoshiuchi, I
- Colilla, S
- Polonsky, K S
- Wei, S
- Concannon, P
- Iwasaki, N
- Schulze, J
- Baier, Leslie J.
- Bogardus, Clifton
- Groop, Leif
- Boerwinkle, Eric
- Hanis, Craig L.
- Bell, Graeme I.
DOIAbstract
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine pr...
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