It is known that parasympathetic, sympathetic and sensory nerves innervate the islets and that these nerves harbor both classical neurotransmitters and neuropeptides. However, the neural influence on islet hormone release is complex and not yet fully understood A recently discovered pancreatic neuropeptide is pituitary adenylate cyclase-activating polypeptide (PACAP). The aim of this thesis was to establish the role of PACAP in the regulation of islet function by using a variety of cell biological techniques in isolated islets and insulin producing clonal cells, in combination with in vivo studies in mice and humans. PACAP was localized to pancreatic nerves within the islets, and two of the three established PACAP receptors were expressed i...
Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and is...
Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-in...
Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and is...
In the pancreatic islets, pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in...
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet neuropeptide with potent insu...
The parasympathetic nerves are important for the regulation of insulin secretion, in particular afte...
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACA...
It has been previously demonstrated that pituitary adenylate cyclase-activating polypeptide (PACAP) ...
The pancreatic islets are richly innervated by autonomic nerves. The islet parasympathetic nerves em...
Although pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin secretion, it...
The cAMP-elevating pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin rel...
Background and aims: Islet function is regulated by islet autonomic nerves. These nerves harbour not...
Objective To study a local effect of pituitary adenylate cyclase activating polypeptide (PACAP1-27) ...
Rat pancreatic alpha- and beta-cells are critically dependent on hormonal signals generating cyclic ...
Chronic exposure of pancreatic islets to elevated plasma lipids ( lipotoxicity) can lead to beta-cel...
Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and is...
Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-in...
Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and is...
In the pancreatic islets, pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed in...
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet neuropeptide with potent insu...
The parasympathetic nerves are important for the regulation of insulin secretion, in particular afte...
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACA...
It has been previously demonstrated that pituitary adenylate cyclase-activating polypeptide (PACAP) ...
The pancreatic islets are richly innervated by autonomic nerves. The islet parasympathetic nerves em...
Although pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin secretion, it...
The cAMP-elevating pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates insulin rel...
Background and aims: Islet function is regulated by islet autonomic nerves. These nerves harbour not...
Objective To study a local effect of pituitary adenylate cyclase activating polypeptide (PACAP1-27) ...
Rat pancreatic alpha- and beta-cells are critically dependent on hormonal signals generating cyclic ...
Chronic exposure of pancreatic islets to elevated plasma lipids ( lipotoxicity) can lead to beta-cel...
Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and is...
Glucagon-like peptide 1 is a gastrointestinally derived hormone with profound effects on nutrient-in...
Islet neogenesis-associated protein (INGAP) is a peptide found in pancreatic exocrine-, duct- and is...