Amyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion proteins have been shown to form dimers by exchange of subdomains of the monomeric proteins. This process, called ?domain swapping?, has also been suggested to play a part in the generation of amyloid fibrils. In the present work the role of this mechanism is investigated. Two variants of wild type and L68Q cystatin C, respectively, with disulfide bonds a...
With the aim to improve our understanding of the structural basis for protein self-association and a...
For several different proteins an apparent correlation has been observed between the propensity for ...
Human cystatin C (HCC), an amyloidogenic protein, forms dimers and higher oligomers (trimers, tetram...
Cystatin C and the prion protein have been shown to form dimers via three-dimensional domain swappin...
Amyloidogenic proteins like cystatin C and prion proteins have been shown to form dimers by exchange...
The crystal structure of human cystatin C, a protein with amyloidogenic properties and a potent inhi...
Human L68Q cystatin C is one of the known human amyloidogenic proteins. In its native state it is a ...
It has been hypothesized that prior to protein domain swapping, unfolding occurs in regions importan...
Many diseases, including Alzheimer's and Creutzfeldt-Jakob disease, are believed to be the result of...
The pathophysiological process in amyloid disorders usually involves the transformation of a functio...
Human cystatin C (HCC) inhibits papain-like cysteine proteases by a binding epitope composed of two ...
Cystatins are natural inhibitors of cysteine proteases, enzymes that are widely distributed in anima...
Human cystatin C (HCC) is a family 2 cystatin inhibitor of papain-like (C1) and legumain-related (C1...
Three dimensional domain swapping is one of the mechanisms involved in formation of insoluble aggreg...
The cystatins were the first amyloidogenic proteins to be shown to oligo-merize through a 3D domain ...
With the aim to improve our understanding of the structural basis for protein self-association and a...
For several different proteins an apparent correlation has been observed between the propensity for ...
Human cystatin C (HCC), an amyloidogenic protein, forms dimers and higher oligomers (trimers, tetram...
Cystatin C and the prion protein have been shown to form dimers via three-dimensional domain swappin...
Amyloidogenic proteins like cystatin C and prion proteins have been shown to form dimers by exchange...
The crystal structure of human cystatin C, a protein with amyloidogenic properties and a potent inhi...
Human L68Q cystatin C is one of the known human amyloidogenic proteins. In its native state it is a ...
It has been hypothesized that prior to protein domain swapping, unfolding occurs in regions importan...
Many diseases, including Alzheimer's and Creutzfeldt-Jakob disease, are believed to be the result of...
The pathophysiological process in amyloid disorders usually involves the transformation of a functio...
Human cystatin C (HCC) inhibits papain-like cysteine proteases by a binding epitope composed of two ...
Cystatins are natural inhibitors of cysteine proteases, enzymes that are widely distributed in anima...
Human cystatin C (HCC) is a family 2 cystatin inhibitor of papain-like (C1) and legumain-related (C1...
Three dimensional domain swapping is one of the mechanisms involved in formation of insoluble aggreg...
The cystatins were the first amyloidogenic proteins to be shown to oligo-merize through a 3D domain ...
With the aim to improve our understanding of the structural basis for protein self-association and a...
For several different proteins an apparent correlation has been observed between the propensity for ...
Human cystatin C (HCC), an amyloidogenic protein, forms dimers and higher oligomers (trimers, tetram...