Human activated protein C (APC) is a key component of a natural anticoagulant system that regulates blood coagulation. In vivo, the catalytic activity of APC is regulated by two serpins, alpha1-antitrypsin and the protein C inhibitor (PCI), the inhibition by the latter being stimulated by heparin. We have identified a heparin-binding site in the serine protease domain of APC and characterized the energetic basis of the interaction with heparin. According to the counter-ion condensation theory, the binding of heparin to APC is 66% ionic in nature and comprises four to six net ionic interactions. To localize the heparin-binding site, five recombinant APC variants containing amino acid exchanges in loops 37, 60, and 70 (chymotrypsinogen number...
Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of fact...
Inactivation of factor Va (FVa) by activated protein C (APC) is a key reaction in the down- regulati...
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases u...
Protein C inhibitor is a plasma protein whose ability to inhibit activated protein C, thrombin, and ...
Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a seri...
Protein C (PC), a 62 kDa multi-modular zymogen, is activated to an anticoagulant serine protease (ac...
AbstractProtein C inhibitor (PCI) is a member of the serpin family that has many biological function...
Protein C inhibitor (PCI) is a multifunctional serpin with wide ranging protease inhibitory function...
Protein C inhibitor (PCI) is a plasma serine proteinase inhibitor (serpin) that is a major physiolog...
Protein C is the central enzyme of the natural anticoagulant pathway and its activated form APC (act...
Protein C is the central enzyme of the natural anticoagulant pathway and its activated form APC (act...
Protein C inhibitor (PCI), a plasma serine protease inhibitor, inhibits several proteases including ...
Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In bl...
Inactivation of factor Va (FVa) by activated protein C (APC) is a predominant mechanism in the down-...
Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (...
Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of fact...
Inactivation of factor Va (FVa) by activated protein C (APC) is a key reaction in the down- regulati...
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases u...
Protein C inhibitor is a plasma protein whose ability to inhibit activated protein C, thrombin, and ...
Anticoagulant protein C is a vitamin K-dependent factor circulating in plasma as a zymogen of a seri...
Protein C (PC), a 62 kDa multi-modular zymogen, is activated to an anticoagulant serine protease (ac...
AbstractProtein C inhibitor (PCI) is a member of the serpin family that has many biological function...
Protein C inhibitor (PCI) is a multifunctional serpin with wide ranging protease inhibitory function...
Protein C inhibitor (PCI) is a plasma serine proteinase inhibitor (serpin) that is a major physiolog...
Protein C is the central enzyme of the natural anticoagulant pathway and its activated form APC (act...
Protein C is the central enzyme of the natural anticoagulant pathway and its activated form APC (act...
Protein C inhibitor (PCI), a plasma serine protease inhibitor, inhibits several proteases including ...
Protein C inhibitor (PCI) is a member of the serpin family that has many biological functions. In bl...
Inactivation of factor Va (FVa) by activated protein C (APC) is a predominant mechanism in the down-...
Protein C (PC) is activated to an essential anticoagulant enzyme (activated PC or APC) by thrombin (...
Activated protein C (APC) down-regulates thrombin formation through proteolytic inactivation of fact...
Inactivation of factor Va (FVa) by activated protein C (APC) is a key reaction in the down- regulati...
Antithrombin, a plasma serpin, is relatively inactive as an inhibitor of the coagulation proteases u...