In the kindling model of epilepsy, repeated electrical stimulations lead to progressive and permanent intensification of seizure activity. We find that the development of amygdala kindling is markedly retarded in mice heterozygous for a deletion of the neurotrophin-3 (NT-3) gene (NT-3+/- mice). These mice did not reach the fully kindled state (3rd grade 5 seizure) until after 28 +/- 4 days of stimulation compared to 17 +/- 2 days in the wild-type animals. The deficit in the NT-3+/- mice reflected dampening of the progression from focal to generalized seizures. The number of stimulations required to evoke focal (grade 1 and 2) seizures did not differ between the groups, but the NT-3 mutants spent a considerably longer period of time (13 +/- ...
In EL mice, ictogenesis has been established at around 10 weeks of age, whereas epileptogenesis will...
In the epileptic brain, seizures can increase hippocampal neurogenesis, while opposingly seizure-ass...
Neurotrophic factors (NTF) play important roles in the developing and in the adult brain. NTF involv...
Epilepsy is a syndrome characterized by recurring attacks of sudden, excessive and synchronous disch...
Levels of messenger RNA for nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, ...
The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modula...
Levels of messenger RNAs for brain-derived neurotrophic factor, nerve growth factor and neurotrophin...
International audienceMesio-temporal lobe epilepsy (MTLE), the most common drug-resistant epilepsy s...
Seizures are marked by a state of irregular, recurrent neuronal activity in the brain. Seizures are ...
SummaryTemporal lobe epilepsy is the most common and often devastating form of human epilepsy. The m...
The Brain-Derived Neurotrophic Factor is one of the most important trophic proteins in the brain. Th...
The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure developme...
Intraventricular 192 IgG-saporin was used to induce a selective lesion of basal forebrain cholinergi...
The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2...
Temporal lobe epilepsy is the most common and often devastating form of human epilepsy. The molecula...
In EL mice, ictogenesis has been established at around 10 weeks of age, whereas epileptogenesis will...
In the epileptic brain, seizures can increase hippocampal neurogenesis, while opposingly seizure-ass...
Neurotrophic factors (NTF) play important roles in the developing and in the adult brain. NTF involv...
Epilepsy is a syndrome characterized by recurring attacks of sudden, excessive and synchronous disch...
Levels of messenger RNA for nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, ...
The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modula...
Levels of messenger RNAs for brain-derived neurotrophic factor, nerve growth factor and neurotrophin...
International audienceMesio-temporal lobe epilepsy (MTLE), the most common drug-resistant epilepsy s...
Seizures are marked by a state of irregular, recurrent neuronal activity in the brain. Seizures are ...
SummaryTemporal lobe epilepsy is the most common and often devastating form of human epilepsy. The m...
The Brain-Derived Neurotrophic Factor is one of the most important trophic proteins in the brain. Th...
The effects of altered N-methyl-D-aspartate (NMDA) receptor subunit composition on seizure developme...
Intraventricular 192 IgG-saporin was used to induce a selective lesion of basal forebrain cholinergi...
The presented thesis explores role of glial cell line derived neurotrophic factor family receptor a2...
Temporal lobe epilepsy is the most common and often devastating form of human epilepsy. The molecula...
In EL mice, ictogenesis has been established at around 10 weeks of age, whereas epileptogenesis will...
In the epileptic brain, seizures can increase hippocampal neurogenesis, while opposingly seizure-ass...
Neurotrophic factors (NTF) play important roles in the developing and in the adult brain. NTF involv...