Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.
- Bennet, Hedvig
- Mollet, Ines
- Balhuizen, Alexander
- Medina Benavente, Anya
- Nagorny, Cecilia
- Bagge, Annika
- Fadista, Joao
- Ottosson Laakso, Emilia
- Vikman, Petter
- Dekker Nitert, Marloes
- Eliasson, Lena
- Wierup, Nils
- Artner, Isabella
- Fex, Malin
Publication date
January 2016
DOI Publisher
Springer Science and Business Media LLCAbstract
The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells
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