At present, clinical outcome or response to therapy can not be fully predicted in individual cases of squamous cell carcinoma of the head and neck (SCCHN). The overall aim of the present studies was to investigate potential prognostic factors, more closely related to the malignant progression of a tumor than the established markers, such as the TNM-classification system. Tumor samples were investigated using cytogenetic analysis, immunohistochemistry (IHC), flow cytometry (FCM), slot blot hybridization, differential PCR and RT-PCR, and fluorescence in situ hybridization (FISH). The findings were compared with clinical data. Rearrangements of chromosome 11, band q13 (11q13), overexpression of the oncoprotein cyclin D1, complex karyotypes, an...
Purpose: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patient...
In this study, the alterations (amplification/rearrangement) of 3 D-type cyclins loci were analyzed ...
Introduction: Several molecular markers have been studied for their usefulness as prognostic markers...
Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck ...
CCND1 amplification results in cyclin D1 overexpression. However, other unidentified genetic mechani...
Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with CCND1 ampli...
Amplification of CCND1 (cyclin D1 gene) in squamous cell carcinoma of the head and neck (SCCHN) is c...
We evaluated the prognostic significance of overexpression of cyclin D1 in 47 patients with surgical...
Despite improvements in both diagnostic and therapeutic strategies, the prognosis of oral squamous c...
The aim of this study was to investigate whether there is an association between overexpression of c...
Chromosome 11q13 amplification has been identified in a subset of head and neck squamous cell carcin...
Introduction: Cyclin D1 oncogene is a key regulator of cell cycle progression associated with variou...
The correlation between cyclin D1 overexpression and the clinical outcome of head and neck cancer is...
We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberr...
It is well established that genetic alterations may be associated to prognosis in tumor patients. Th...
Purpose: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patient...
In this study, the alterations (amplification/rearrangement) of 3 D-type cyclins loci were analyzed ...
Introduction: Several molecular markers have been studied for their usefulness as prognostic markers...
Abnormalities of chromosome band 11q13 are frequent in squamous cell carcinoma of the head and neck ...
CCND1 amplification results in cyclin D1 overexpression. However, other unidentified genetic mechani...
Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with CCND1 ampli...
Amplification of CCND1 (cyclin D1 gene) in squamous cell carcinoma of the head and neck (SCCHN) is c...
We evaluated the prognostic significance of overexpression of cyclin D1 in 47 patients with surgical...
Despite improvements in both diagnostic and therapeutic strategies, the prognosis of oral squamous c...
The aim of this study was to investigate whether there is an association between overexpression of c...
Chromosome 11q13 amplification has been identified in a subset of head and neck squamous cell carcin...
Introduction: Cyclin D1 oncogene is a key regulator of cell cycle progression associated with variou...
The correlation between cyclin D1 overexpression and the clinical outcome of head and neck cancer is...
We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberr...
It is well established that genetic alterations may be associated to prognosis in tumor patients. Th...
Purpose: Genetic biomarkers of head and neck tumors could be useful for distinguishing among patient...
In this study, the alterations (amplification/rearrangement) of 3 D-type cyclins loci were analyzed ...
Introduction: Several molecular markers have been studied for their usefulness as prognostic markers...