High risks of maternal and perinatal complications in singletons born after oocyte donation

INTRODUCTION: Previous studies have shown an increased risk of obstetric complications in pregnancies after oocyte donation (OD). The present study includes all singletons born after OD during 10 years in Sweden.MATERIAL AND METHODS: A retrospective cohort study that included data from all Swedish in vitro fertilization (IVF) clinics between 2003 and 2012 was performed. Data were cross-linked with the Swedish Medical Birth Registry. The study included 388 OD singletons, 26,696 IVF/ICSI singletons and 999,804 spontaneously conceived (SC) singletons. Adjusted odds ratio (AOR) was calculated with adjustment for relevant confounders.RESULTS: Singleton OD pregnancies had a significantly increased risk of preeclampsia compared to IVF (AOR 3.05; 95% CI 2.23-4.16) and SC (AOR 2.84; 95% CI 2.10-3.84), increased risk of postpartum hemorrhage (>1000 ml) compared to IVF (AOR 2.66; 95% CI 2.04-3.49) and SC (AOR 2.87; 95% CI 2.20-3.71), higher risk of preterm birth (<37) compared to IVF (AOR 1.79; 95% CI 1.30-2.46) and SC (AOR 1.58; 95% CI 1.15-2.16) and low birth weight (