Genetic Risk Prediction of Atrial Fibrillation
- Lubitz, Steven A
- Yin, Xiaoyan
- Lin, Henry J.
- Kolek, Matthew
- Smith, Gustav G.
- Trompet, Stella
- Rienstra, Michiel
- Rost, Natalia S.
- Teixeira, Pedro L.
- Almgren, Peter
- Anderson, Christopher D.
- Chen, Lin Y.
- Engström, Gunnar
- Ford, Ian
- Furie, Karen L.
- Guo, Xiuqing
- Larson, Martin G.
- Lunetta, Kathryn L.
- Macfarlane, Peter W
- Psaty, Bruce M.
- Soliman, Elsayed Z
- Sotoodehnia, Nona
- Stott, David J.
- Taylor, Kent D
- Weng, Lu Chen
- Yao, Jie
- Geelhoed, Bastiaan
- Verweij, Niek
- Siland, Joylene E.
- Kathiresan, Sekar
- Roselli, Carolina
- Roden, Dan M
- van der Harst, Pim
- Darbar, Dawood
- Jukema, J. Wouter
- Melander, Olle
- Rosand, Jonathan
- Rotter, Jerome I.
- Heckbert, Susan R
- Ellinor, Patrick T
- Alonso, Alvaro
- Benjamin, Emelia J
- on behalf of the AFGen Consortium
DOIAbstract
BACKGROUND—: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals at greatest AF risk could minimize the incidence of cardioembolic stroke. METHODS—: To determine whether genetic data can stratify risk for development of AF, we examined associations between AF genetic risk scores and incident AF in five prospective studies comprising 18,919 individuals of European ancestry. We examined associations between AF genetic risk scores and ischemic stroke in a separate study of 509 ischemic stroke cases (202 cardioembolic [40%]) and 3,028 referents. Scores were based on 11 to 719 common variants (≥5%) associated with AF at P-values ranging from <1x10 to <1x10 in a prior independent genetic association study. RESU...
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