Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
- Wu, G.
- Broniscer, A.
- McEachron, T.
- Lu, C.
- Paugh, B.
- Becksfort, J.
- Qu, C.
- Ding, L.
- Huether, R.
- Parker, M.
- Zhang, J.
- Gajjar, A.
- Dyer, M.
- Mullighan, C.
- Gilbertson, R.
- Mardis, E.
- Wilson, R.
- Downing, J.
- Ellison, D.
- Zhang, J.
- et al.
DOIAbstract
To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.Gang Wu, Alberto Broniscer, Troy A McEachron, Charles Lu, Barbara S Paugh, Jared Becksfort, Chunxu Qu, Li Ding, Robert Huether, Matthew Parker, Junyuan Z...
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