Recent scientific research arguably confirms the existence of a remarkable phenomenon: durable psychological benefit to an individual resulting from a single ingestion of a psychedelic drug. In this thesis by publication I ask what exactly is going on in such cases of 'psychedelic transformation'. The thesis is situated in the context of a resurgence of interest in psychedelics within neuroscience and psychiatry, and motivated by the need for philosophical examination of the foundations and results of this research program. Two common claims in the literature on therapeutic and transformative uses of psychedelics are: (a) psychedelic experiences are a reliable means of knowledge acquisition or spiritual growth, and (b) such epistemic or spi...