Add to ORKGThe circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21
Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whet...
Metabolic activities are regulated by the circadian clock, and disruption of the clock exacerbates m...
The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominan...
The circadian clock contributes to the timing of many body functions including metabolism and reprod...
The circadian clock contributes to the timing of many body functions including metabolism and reprod...
Circadian and metabolic physiology are intricately intertwined. Although the liver clock is entraine...
Circadian and metabolic physiology are intricately intertwined. Although the liver clock is entraine...
AbstractPeroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates th...
The molecular clock is a master controller of circadian cellular processes that affect growth, metab...
Rev-erbα is a member of the nuclear receptor family and was cloned by Mitchell Lazar and colleagues ...
Rev-erbα is a constitutive transcriptional repressor and highly expressed in liver, skeletal muscle ...
In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coor...
The mammalian circadian clock is composed of interlocking feedback loops. Cryptochrome is a central ...
AbstractNormal physiological processes are under control of circadian rhythms. Moreover, certain pat...
Summary : PPARα is a ligand-activated transcription factor that is a member of the nuclear receptor ...
Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whet...
Metabolic activities are regulated by the circadian clock, and disruption of the clock exacerbates m...
The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominan...
The circadian clock contributes to the timing of many body functions including metabolism and reprod...
The circadian clock contributes to the timing of many body functions including metabolism and reprod...
Circadian and metabolic physiology are intricately intertwined. Although the liver clock is entraine...
Circadian and metabolic physiology are intricately intertwined. Although the liver clock is entraine...
AbstractPeroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates th...
The molecular clock is a master controller of circadian cellular processes that affect growth, metab...
Rev-erbα is a member of the nuclear receptor family and was cloned by Mitchell Lazar and colleagues ...
Rev-erbα is a constitutive transcriptional repressor and highly expressed in liver, skeletal muscle ...
In mammals, many aspects of behavior and physiology, and in particular cellular metabolism, are coor...
The mammalian circadian clock is composed of interlocking feedback loops. Cryptochrome is a central ...
AbstractNormal physiological processes are under control of circadian rhythms. Moreover, certain pat...
Summary : PPARα is a ligand-activated transcription factor that is a member of the nuclear receptor ...
Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whet...
Metabolic activities are regulated by the circadian clock, and disruption of the clock exacerbates m...
The nuclear receptor REVERBα is a core component of the circadian clock and proposed to be a dominan...