Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review
- Hellquist, H.
- Skalova, A.
- Barnes, L.
- Cardesa, A.
- Thompson, L.D.
- Triantafyllou, A.
- Williams, M.D.
- Devaney, K.O.
- Gnepp, D.R.
- Bishop, J.A.
- Wenig, B.M.
- Suarez, C.
- Rodrigo, J.P.
- Coca-Pelaz, A.
- Strojan, P.
- Shah, J.P.
- Hamoir, M.
- Bradley, P.J.
- Silver, C.E.
- Slootweg, P.J.
- Poorten, V. Van der
- Teymoortash, A.
- Medina, J.E.
- Robbins, K.T.
- Pitman, K.T.
- Kowalski, L.P.
- Bree, R. de
- Mendenhall, W.M.
- Eloy, J.A.
- Takes, R.P.
- Rinaldo, A.
- Ferlito, A.
DOIAbstract
Contains fulltext : 172098.pdf (Publisher’s version ) (Open Access)Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this ...
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