Meta-analysis of the DRD5 VNTR in persistent ADHD

Klein, M.
Berger, S.
Hoogman, M.
Dammers, J.T.
Makkinje, R.R.
Heister, A.
Galesloot, T.E.
Kiemeney, L.A.
Weber, H.
Kittel-Schneider, S.
Lesch, K.P.
Reif, A.
Ribases, M.
Ramos-Quiroga, J.A.
Cormand, B.
Zayats, T.
Hegvik, T.A.
Jacobsen, K.K.
Johansson, S.
Haavik, J.
Mota, N.R.
Bau, C.H.
Grevet, E.H.
Doyle, A.
Faraone, S.V
Arias-Vasquez, A.
Franke, B.

Open link

Publication date

January 2016

DOI

10.1016/j.euroneuro.2016.06.012

Publisher

Elsevier BV

ISSN

0924-977X

Citation count (estimate)

Abstract

Contains fulltext : 167943pub.pdf (publisher's version ) (Closed access)Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neuropsychiatric disorder with a complex genetic background. DRD5, the gene encoding the dopamine receptor D5, was recently confirmed as a candidate gene for ADHD in children through meta-analysis. In this study, we aimed at studying the association of the ADHD-associated variable number tandem repeat (VNTR) polymorphism upstream of DRD5 with adult ADHD. We compiled data from six sites of the International Multicentre persistent ADHD CollaboraTion (IMpACT) and reached N=6979 (3344 cases and 3635 healthy participants), the largest sample investigated so far. We tested the association of the com...