Add to ORKGBackground: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycolytic metabolism of cancer cells. Methods: GLUT12 expression was determined by immunohistochemistry in a selection of cancer cell lines and a tumour spheroid model. Results: GLUT12 expression was high in A549 and RH-36; low in HT29; and absent in NB-EB cancer cell lines. GLUT12 expression was located in the necrotic centre of HT29 spheroids, which is characterised by anaerobic metabolism. Conclusion: The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and therefore, its potential as a novel therapeutic target for cancer treatment
BACKGROUND: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute...
Most cancers of various tissue origin show large portions suffering from permanent or transient hypo...
Background: Due to proliferation and increased metabolism, cancer cells have high glucose requiremen...
Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycoly...
The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and theref...
The facilitative glucose transporter Glut-1 is overexpressed and confers poor prognosis in a wide ra...
The facilitative glucose transporter Glut-1 is overexpressed and confers poor prognosis in a wide ra...
The altered metabolism observed in cancer cells generally consists of increased glucose uptake and g...
Abstract Alterations in nutritional uptake and metabolism is a crucial hallmark of cancer. As cancer...
Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark. The deviant ...
Glucose utilization increases in tumors, a metabolic process that is observed clinically by <sup&...
Human GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. Glucose...
PURPOSE OF THE REPORT: Extrahepatic bile duct (EHD) cancer varies in uptake of FDG. The aim of the p...
OBJECTIVE: To analyze glucose transporter 1 expression patterns in malignant tumors of various cell ...
Purpose: Glucose uptake and glycolytic metabolism are enhanced in cancer cells, and increased expres...
BACKGROUND: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute...
Most cancers of various tissue origin show large portions suffering from permanent or transient hypo...
Background: Due to proliferation and increased metabolism, cancer cells have high glucose requiremen...
Background: Recent studies proposed GLUT12 to be a major glucose transporter involved in the glycoly...
The data supports the involvement of GLUT12 in the glycolytic metabolism of cancer cells and theref...
The facilitative glucose transporter Glut-1 is overexpressed and confers poor prognosis in a wide ra...
The facilitative glucose transporter Glut-1 is overexpressed and confers poor prognosis in a wide ra...
The altered metabolism observed in cancer cells generally consists of increased glucose uptake and g...
Abstract Alterations in nutritional uptake and metabolism is a crucial hallmark of cancer. As cancer...
Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark. The deviant ...
Glucose utilization increases in tumors, a metabolic process that is observed clinically by <sup&...
Human GLUT12 was isolated from the breast cancer cell line MCF-7 by its homology with GLUT4. Glucose...
PURPOSE OF THE REPORT: Extrahepatic bile duct (EHD) cancer varies in uptake of FDG. The aim of the p...
OBJECTIVE: To analyze glucose transporter 1 expression patterns in malignant tumors of various cell ...
Purpose: Glucose uptake and glycolytic metabolism are enhanced in cancer cells, and increased expres...
BACKGROUND: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute...
Most cancers of various tissue origin show large portions suffering from permanent or transient hypo...
Background: Due to proliferation and increased metabolism, cancer cells have high glucose requiremen...