Add to ORKGBackground: IFN-alpha 5 has been demonstrated to induce stronger signaling and higher expression of antiviral genes than IFN-alpha 2, which is the current treatment in chronic viral hepatitis. However, there is no specific and validated quantification method in order to conduct kinetic studies as part of the preclinical and clinical evaluation for regulatory purposes. Results: A novel integration of an antiviral assay against the cytopathic effect of the encephalomyocarditis virus in HeLa cells with a very sensitive method for assay processing - the Vialight (R) Plus assay - is presented for IFN-alpha 5 activity quantification. The bioassay has been validated in macaque and human serum and it has been demonstrated to be selective, precise a...
Since the discovery of the hepatitis C virus, the goal of all treatment is to clear the virus and no...
The aim of the project was to investigate the mechanism by which HCV evades therapeutic IFN treatmen...
INTRODUCTION: The pandemic spread of a new coronavirus infection, COVID-19, has caused a global emer...
Background: IFN-alpha 5 has been demonstrated to induce stronger signaling and higher expression of ...
The biotherapeutic type I interferons (IFN-I) are indicated to treat several diseases. These product...
Type I interferons (IFN) comprise a family of cytokines that signal through a common cellular recept...
For more than three decades, IFN-α2b has been widely used for the treatment of multiple human viral ...
The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of the ...
peer reviewedThe interferons (IFNs) are a primary defense against pathogens because of the strong an...
The interferon (IFN) system is the first line of defense against viral infections. Evasion of IFN si...
Specific antiviral activity is one of the key indicators characterising pharmaceutical quality and p...
p. 1-15Background IFN-α contributes extensively to host immune response upon viral infection through...
Having been used in hepatitis B therapy for more than 20 years, interferon-alpha (IFN-α) is st...
Introduction: Hepatitis C virus (HCV) infections remain an increasingly prevalent and emergent healt...
International audienceBackground: Nucleic acid testing is essential for the detection and quantifica...
Since the discovery of the hepatitis C virus, the goal of all treatment is to clear the virus and no...
The aim of the project was to investigate the mechanism by which HCV evades therapeutic IFN treatmen...
INTRODUCTION: The pandemic spread of a new coronavirus infection, COVID-19, has caused a global emer...
Background: IFN-alpha 5 has been demonstrated to induce stronger signaling and higher expression of ...
The biotherapeutic type I interferons (IFN-I) are indicated to treat several diseases. These product...
Type I interferons (IFN) comprise a family of cytokines that signal through a common cellular recept...
For more than three decades, IFN-α2b has been widely used for the treatment of multiple human viral ...
The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of the ...
peer reviewedThe interferons (IFNs) are a primary defense against pathogens because of the strong an...
The interferon (IFN) system is the first line of defense against viral infections. Evasion of IFN si...
Specific antiviral activity is one of the key indicators characterising pharmaceutical quality and p...
p. 1-15Background IFN-α contributes extensively to host immune response upon viral infection through...
Having been used in hepatitis B therapy for more than 20 years, interferon-alpha (IFN-α) is st...
Introduction: Hepatitis C virus (HCV) infections remain an increasingly prevalent and emergent healt...
International audienceBackground: Nucleic acid testing is essential for the detection and quantifica...
Since the discovery of the hepatitis C virus, the goal of all treatment is to clear the virus and no...
The aim of the project was to investigate the mechanism by which HCV evades therapeutic IFN treatmen...
INTRODUCTION: The pandemic spread of a new coronavirus infection, COVID-19, has caused a global emer...