Add to ORKGOBJECTIVE: Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human vascular smooth muscle cells (VSMC). METHODS AND RESULTS: In asymptomatic subjects, circulating CCL20 levels were higher in patients with hypercholesterolemia (18.5±3.2 versus 9.1±1.3 pg/mL; P<0.01). LDL induced the expression of CCL20 in VSMC in a dose- and time-dependent manner. Increased levels of CCL20 secreted by LDL-treated VSMC significantly induced human lymphocyte migration, an effect reduced by CCL20 silencing. The upregulation of CCL20 by LDL was dependent on the activation of kinase signaling pathways and NF-κB. By site-directed mutagenesis, electrophoretic mobility shift assay, and chromatin immunoprecipitation, we identified a N...
The data presented in this article is related to the research article entitled “ABCA1 and HDL3 are R...
Objective-Despite common disbelief that neutrophils are involved in atherosclerosis, evidence is acc...
Objective—Low density lipoprotein (LDL) receptor–related protein (LRP) binds and internalizes aggreg...
OBJECTIVE: Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human v...
Objective—Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human va...
The inflammatory chemokines CCL2, CCL5, and CX₃CL1 stimulate vascular smooth muscle cell (SMC) proli...
Aims The homeostatic chemokines, CCL19 and CCL21 and their receptor CCR7, have recently been linked ...
Defective LDL-C clearance and hence its elevation in the circulation is an established risk factor f...
Background/Aims: We determined growth rates, cholesterol esterification and mRNA levels for caveolin...
OBJECTIVE: The presence of small dense LDL has been associated with increased cardiovascular risk ...
Low-density lipoprotein (LDL) induces cell proliferation in human aortic smooth muscle cells (hAoSMC...
OBJECTIVE-: The purpose of this study was to investigate the ability of high-density lipoproteins (H...
Recent genetic studies have implicated pro-inflammatory chemokines and chemokine receptors in athero...
Chemokines play a crucial role in inflammation and in the pathophysiology of atherosclerosis by recr...
Objective: Vascular smooth muscle cell (VSMC) migration and proliferation are key components of vasc...
The data presented in this article is related to the research article entitled “ABCA1 and HDL3 are R...
Objective-Despite common disbelief that neutrophils are involved in atherosclerosis, evidence is acc...
Objective—Low density lipoprotein (LDL) receptor–related protein (LRP) binds and internalizes aggreg...
OBJECTIVE: Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human v...
Objective—Our aim was to analyze the regulation of CC Chemokine ligand 20 (CCL20) by LDL in human va...
The inflammatory chemokines CCL2, CCL5, and CX₃CL1 stimulate vascular smooth muscle cell (SMC) proli...
Aims The homeostatic chemokines, CCL19 and CCL21 and their receptor CCR7, have recently been linked ...
Defective LDL-C clearance and hence its elevation in the circulation is an established risk factor f...
Background/Aims: We determined growth rates, cholesterol esterification and mRNA levels for caveolin...
OBJECTIVE: The presence of small dense LDL has been associated with increased cardiovascular risk ...
Low-density lipoprotein (LDL) induces cell proliferation in human aortic smooth muscle cells (hAoSMC...
OBJECTIVE-: The purpose of this study was to investigate the ability of high-density lipoproteins (H...
Recent genetic studies have implicated pro-inflammatory chemokines and chemokine receptors in athero...
Chemokines play a crucial role in inflammation and in the pathophysiology of atherosclerosis by recr...
Objective: Vascular smooth muscle cell (VSMC) migration and proliferation are key components of vasc...
The data presented in this article is related to the research article entitled “ABCA1 and HDL3 are R...
Objective-Despite common disbelief that neutrophils are involved in atherosclerosis, evidence is acc...
Objective—Low density lipoprotein (LDL) receptor–related protein (LRP) binds and internalizes aggreg...