Add to ORKGThe project was focused on the synthesis, structural elucidation and in vitro pharmacology of novel ligands for the histamine receptor subtypes H1R, H2R, H3R and H4R with the aim to further characterize the structure-activity relationships in this field
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Science...
Covalent binding of G protein-coupled receptors by small molecules is a useful approach for better u...
Wstęp pracy zawiera krótką charakterystykę receptorów H3 histaminowych z uwzględnieniem ich struktur...
New classes of alkylated hetarylpropylguanidines with different functionality and variation in space...
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like...
In previous studies NG-acylated imidazolylpropylguanidines, originally developed as histamine H2 rec...
The recently discovered histamine H4 receptor (H4R) is reported to be involved in immunological proc...
N(1)-Aryl(heteroaryl)alkyl-N(2)-[3-(1H-imidazol-4-yl)propyl]guanidines are potent histamine H2-recep...
2-Cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-[2-(phenylsulfanypethyl]guanidine (UR-PI376, 1) is a potent ...
Starting from a known H(4)R ligand based on a pyrimidine skeleton, a series of novel analogues based...
A series of tetrahydrofuran based compounds with a bicyclic core that provides conformational restri...
A class of rigid, dibasic, non-imidazole H3 antagonists was developed, starting from a series of pre...
3-(1H-imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at th...
Since identification and cloning of the histamine H4 receptor (H4R) in 2000 by several groups, the d...
2-Cyano-1-[4-(1<i>H</i>-imidazol-4-yl)butyl]-3-[2-(phenylsulfanyl)ethyl]guanidine (UR-PI376, <b>1...
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Science...
Covalent binding of G protein-coupled receptors by small molecules is a useful approach for better u...
Wstęp pracy zawiera krótką charakterystykę receptorów H3 histaminowych z uwzględnieniem ich struktur...
New classes of alkylated hetarylpropylguanidines with different functionality and variation in space...
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like...
In previous studies NG-acylated imidazolylpropylguanidines, originally developed as histamine H2 rec...
The recently discovered histamine H4 receptor (H4R) is reported to be involved in immunological proc...
N(1)-Aryl(heteroaryl)alkyl-N(2)-[3-(1H-imidazol-4-yl)propyl]guanidines are potent histamine H2-recep...
2-Cyano-1-[4-(1H-imidazol-4-yl)butyl]-3-[2-(phenylsulfanypethyl]guanidine (UR-PI376, 1) is a potent ...
Starting from a known H(4)R ligand based on a pyrimidine skeleton, a series of novel analogues based...
A series of tetrahydrofuran based compounds with a bicyclic core that provides conformational restri...
A class of rigid, dibasic, non-imidazole H3 antagonists was developed, starting from a series of pre...
3-(1H-imidazol-4-yl)propylguanidine (SK&F 91486, 4) was identified as a potent partial agonist at th...
Since identification and cloning of the histamine H4 receptor (H4R) in 2000 by several groups, the d...
2-Cyano-1-[4-(1<i>H</i>-imidazol-4-yl)butyl]-3-[2-(phenylsulfanyl)ethyl]guanidine (UR-PI376, <b>1...
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Science...
Covalent binding of G protein-coupled receptors by small molecules is a useful approach for better u...
Wstęp pracy zawiera krótką charakterystykę receptorów H3 histaminowych z uwzględnieniem ich struktur...