A new radiosynthetic protocol for the preparation of [[superscript 11]C]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L·Pd(Ar)X complexes (L = biaryl phosphine) with [[superscript 11]C]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [[superscript 11]C]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency.National Institutes of Health (U.S.) (NIH GM46059)National Science Foundation (U.S.) (NSF predoctoral fellowship (2010094243))Amgen Inc. (Educational donation)National Institutes of He...
We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-[11C]carbo...
Carbon-11 offers the unique possibility of authentic labelling of moiecules as radioindicators for n...
Objectives: The [11C](R)-PK11195 ((R)-1-(2-chlorophenyl)-N-1-[11C]methyl-N-(1-propyl)-3-isoquinoline...
A new radiosynthetic protocol for the preparation of [C-11]aryl nitriles has been developed. This pr...
A new radiosynthetic protocol for the preparation of [<sup>11</sup>C]aryl nitriles has been develop...
A robust and high-yielding radiochemical synthesis of ¹¹C-N-cyanobenzamides using a palladium-mediat...
This thesis focuses on the requirement for new methodologies to incorporate 11C into biologically a...
A novel radiolabelling method exploiting 11C-dithiocarbamate ligands has been used to generate 11C-l...
Copper-mediated 11C-cyanation reactions have enabled the synthesis of PET radiotracers from a range ...
Introduction. [11C]Cyanide has been used as a useful intermediate for incorporation of 11C-labelled ...
Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammo...
This thesis focuses on the requirement for new methodologies to incorporate 11C into biologically ac...
The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for po...
Objectives: Introduction of carbonyl moiety into an aryl or heteroaryl group are powerful processes ...
Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found exte...
We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-[11C]carbo...
Carbon-11 offers the unique possibility of authentic labelling of moiecules as radioindicators for n...
Objectives: The [11C](R)-PK11195 ((R)-1-(2-chlorophenyl)-N-1-[11C]methyl-N-(1-propyl)-3-isoquinoline...
A new radiosynthetic protocol for the preparation of [C-11]aryl nitriles has been developed. This pr...
A new radiosynthetic protocol for the preparation of [<sup>11</sup>C]aryl nitriles has been develop...
A robust and high-yielding radiochemical synthesis of ¹¹C-N-cyanobenzamides using a palladium-mediat...
This thesis focuses on the requirement for new methodologies to incorporate 11C into biologically a...
A novel radiolabelling method exploiting 11C-dithiocarbamate ligands has been used to generate 11C-l...
Copper-mediated 11C-cyanation reactions have enabled the synthesis of PET radiotracers from a range ...
Introduction. [11C]Cyanide has been used as a useful intermediate for incorporation of 11C-labelled ...
Herein we report the preparation of ammonium [11C]thiocyanate via the reaction of [11C]CS2 with ammo...
This thesis focuses on the requirement for new methodologies to incorporate 11C into biologically ac...
The cross-coupling of aryl bromides with [11C]CH3Li for the labelling of a variety of tracers for po...
Objectives: Introduction of carbonyl moiety into an aryl or heteroaryl group are powerful processes ...
Positron emission tomography (PET) is a non-invasive molecular imaging technique that has found exte...
We have developed 8-amino-3-(2S,5R-dimethyl-1-piperidyl)-[1,2,4]triazolo[4,3-a]pyrazine-5-[11C]carbo...
Carbon-11 offers the unique possibility of authentic labelling of moiecules as radioindicators for n...
Objectives: The [11C](R)-PK11195 ((R)-1-(2-chlorophenyl)-N-1-[11C]methyl-N-(1-propyl)-3-isoquinoline...