Dosimetric evaluation of daily rigid and nonrigid geometric correction strategies during on-line image-guided radiation therapy (IGRT) of prostate cancer.

The purpose of this study is to evaluate a geometric image guidance strategy that simultaneously correct for various inter-fractional rigid and nonrigid geometric uncertainties in an on-line environment, using field shape corrections (called the MU-MLC technique). The effectiveness of this strategy was compared with two other simpler on-line image guidance strategies that are more commonly used in the clinic. To this end, five prostate cancer patients, with at least 15 treatment CT studies each, were analyzed. The prescription dose was set to the maximum dose that did not violate the rectum and bladder dose-volume constraints, and hence, was unique to each patient. Deformable image registration and dose-tracking was performed on each CT image to obtain the cumulative treatment dose distributions. From this, maximum, minimum, and mean dose, as well as generalized equivalent uniform dose (gEUD) were calculated for each image guidance strategy. As expected, some dosimetric differences in the clinical target volume (CTV) were observed between the three image guidance strategies investigated. For example, up to +/-2% discrepancy in prostate minimum dose were observed among the techniques. Of them, only the MU -MLC technique did not reduce the prostate minimum dose for all patients (i.e., \u3e or = 100%). However, the differences were clinically not significant to indicate the preference of one strategy over another, when using a uniform 5 mm margin size. For the organ-at-risks (OARs), the large rectum sparing effect (\u3c or =5.7 Gy, gEUD) and bladder overdosing effect (\u3c or = 16 Gy, gEUD) were observed. This was likely due to the use of bladder contrast during CT simulation studies which was not done during the treatment CT studies. Therefore, ultimately, strategies to maintain relatively constant rectum and bladder volumes, throughout the treatment course, are required to minimize this effect. In conclusion, the results here suggest that simple translational corrections based on three-dimensional (3D) images is adequate to maintain target coverage, for margin sizes at least as large as 5 mm. In addition, due to large fluctuations in OAR volumes, innovative image guidance strategies are needed to minimize dose and maintain consistent sparing during the whole course of radiation therapy