Project of RISEGrid institute (EDF-CentraleSupelec)International audienceIn recent years, co-simulation has become an increasingly industrial tool to simulate Cyber Physical Systems including multi-physics and control, like smart electric grids, since it allows to involve different modeling tools within the same temporal simulation. The challenge now is to integrate in a single calculation scheme very numerous and intensely interconnected models, and to do it without any loss in model accuracy. This will avoid neglecting fine phenomena or moving away from the basic principle of equation-based modeling. Offering both a large number of computing cores and a large amount of distributed memory, multi-core PC clusters can address this key issue ...