Identification of a Region That Assists Membrane Insertion and Translocation of the Catalytic Domain of Bordetella pertussis CyaA Toxin
- Karst, Johanna C.
- Barker, Robert
- Devi, Usha
- Swann, Marcus J.
- Davi, Marilyne
- Roser, Stephen J.
- Ladant, Daniel
- Chenal, Alexandre
Publication date
January 2012
DOI Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)Abstract
International audienceBackground: Translocation of the CyaA toxin across plasma membrane is still poorly understood. Results: The region 375– 485 is involved in membrane destabilization in vitro and required for cell intoxication. Conclusion: The region 375– 485 is crucial for membrane insertion and translocation of the catalytic domain of CyaA. Significance: These results provide new insights on the early stages of the cell intoxication process
Add to ORKG