Add to ORKGLactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to signal through the G protein coupled receptor 81 (GPR81) and to thus modulate inflammatory processes. This study demonstrates that lactate inhibits pro-inflammatory signaling in a GPR81-independent fashion. While lipopolysaccharide (LPS) triggered expression of IL-6 and IL-12 p40, and CD40 in bone marrow-derived macrophages, lactate was able to abrogate these responses in a dose dependent manner in Gpr81-/- cells as well as in wild type cells. Macrophage activation was impaired when glycolysis was blocked by chemical inhibitors. Remarkably, lactate was found to inhibit LPS-induced glycolysis in wild type as well as in Gpr81-/- cells. In conclus...
<div><p>Lactate has long been considered a “waste” by-product of cell metabolism, and it accumulates...
Supported by a fellowship from the Arthritis Research UK to VP and by a fellowship from...
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been de...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to si...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to si...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to si...
Lactate, the end product of anaerobic glycolysis, is produced in high amounts by innate immune cells...
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate im...
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the a...
Lactate and the associated H+ ions are still introduced in many biochemistry and general biology tex...
IntroductionLactate secreted by tumors is not just a byproduct, but rather an active modulator of im...
In order to mount an appropriate immune response to infection, the macrophage must alter its metabol...
International audienceLactate has long been considered as a metabolic by-product of cells. Recently,...
Lactate is an end point of Warburg-type metabolism found in inflammatory macrophages. Recently, lact...
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for...
<div><p>Lactate has long been considered a “waste” by-product of cell metabolism, and it accumulates...
Supported by a fellowship from the Arthritis Research UK to VP and by a fellowship from...
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been de...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to si...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to si...
Lactate is an essential component of carbon metabolism in mammals. Recently, lactate was shown to si...
Lactate, the end product of anaerobic glycolysis, is produced in high amounts by innate immune cells...
Recent evidence from cancer research indicates that lactate exerts a suppressive effect on innate im...
Lactate is a by-product of glycolysis that can function via its G protein receptor GPR81. Here the a...
Lactate and the associated H+ ions are still introduced in many biochemistry and general biology tex...
IntroductionLactate secreted by tumors is not just a byproduct, but rather an active modulator of im...
In order to mount an appropriate immune response to infection, the macrophage must alter its metabol...
International audienceLactate has long been considered as a metabolic by-product of cells. Recently,...
Lactate is an end point of Warburg-type metabolism found in inflammatory macrophages. Recently, lact...
Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis for...
<div><p>Lactate has long been considered a “waste” by-product of cell metabolism, and it accumulates...
Supported by a fellowship from the Arthritis Research UK to VP and by a fellowship from...
GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been de...