Treatments for Parkinson’s disease face significant challenges in delivery to the due to the presence of blood brain barrier (BBB). The aim of this study was to develop and characterise an in-situ thermoresponsive polymer based gel system for possible exploitation of the intranasal olfactory route where the BBB is absent. Reaching the olfactory region in the nasal cavity and mucociliary clearance are the main hurdles from formulation point of view. Thermo-sensitive and pH sensitive polymers seem to be the answer to these problems. Formulation made with these polymers along with mucoadhesives will be liquid at room temperature and will turn into a viscous gel when comes in contact with the body either due to change in pH or temperature. We h...
Thermosensitive in situ gels are promising formulations for the management of Alzheimer’s disease (A...
Over the past ten years, in situ gelling drug delivery methods have attracted a lot of attention. Pr...
The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranas...
The aim of this study was to develop and characterise an intranasal delivery system for amantadine (...
The aim of this study was to develop and characterize an intranasal delivery system for amantadine h...
Parkinson’s disease is a disabling neurodegenerative disease which limits many functional activities...
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit o...
The blood brain barrier (BBB) poses a significant hurdle to brain drug delivery. However, the locati...
Mitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease (PD...
The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranas...
Rasagiline mesylate (RSM) is a hydrophilic drug with poor oral bioavailability (36%) because of hepa...
The purpose of the present work was to develop a mucoadhesive thermoreversible nasal gel with a tail...
Copyright © 2014 A. Naik and H. Nair.This is an open access article distributed under the Creative C...
This paper reports the use of a self-assembling hydrogel as a delivery vehicle for the Parkinson’s d...
In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therape...
Thermosensitive in situ gels are promising formulations for the management of Alzheimer’s disease (A...
Over the past ten years, in situ gelling drug delivery methods have attracted a lot of attention. Pr...
The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranas...
The aim of this study was to develop and characterise an intranasal delivery system for amantadine (...
The aim of this study was to develop and characterize an intranasal delivery system for amantadine h...
Parkinson’s disease is a disabling neurodegenerative disease which limits many functional activities...
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit o...
The blood brain barrier (BBB) poses a significant hurdle to brain drug delivery. However, the locati...
Mitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease (PD...
The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranas...
Rasagiline mesylate (RSM) is a hydrophilic drug with poor oral bioavailability (36%) because of hepa...
The purpose of the present work was to develop a mucoadhesive thermoreversible nasal gel with a tail...
Copyright © 2014 A. Naik and H. Nair.This is an open access article distributed under the Creative C...
This paper reports the use of a self-assembling hydrogel as a delivery vehicle for the Parkinson’s d...
In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the therape...
Thermosensitive in situ gels are promising formulations for the management of Alzheimer’s disease (A...
Over the past ten years, in situ gelling drug delivery methods have attracted a lot of attention. Pr...
The prolonged residence of drug formulation in the nasal cavity is of utmost importance for intranas...