Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design

Perry, M. J.
Mendes, E.
Simplício, A. L.
Coelho, A.
Iley, J.
Moreira, R.
Francisco, A. P.

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Publication date

January 2009

DOI

10.1016/j.ejmech.2009.03.025

Publisher

Elsevier BV

ISSN

0223-5234

Language

English

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Abstract

We report the synthesis of triazene derivatives, and their evaluation as substrates for tyrosinase. The conversion of prodrugs to the ortho-quinone was confirmed by LC-MS

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Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design

Abstract

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Dopamine- and tyramine-based derivatives of triazenes. Activation by tyrosinase and implications for prodrug design

Abstract

Extracted data

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