A number of drugs were assessed for their ability to inhibit stimulus-evoked prostanoid synthesis in cultured glia. These drugs included non-selective cyclooxygenase (COX) inhibitors and those considered to be selective for the inducible isoform of this enzyme (COX-2). Experiments were carried out on normal cultures and those which had been maintained in serum-free growth medium for four days then re-exposed to serum for a further seven days. All of the drugs tested elicited concentration-dependent inhibitions of arachidonic acid (AA)-stimulated thromboxane B2 (TXB2) accumulation in normal cultures with the following rank order of potency: indomethacin > piroxicam > nimesulide = NS398 > ibuprofen ≫ aspirin > paracetamol. In cultures which h...
Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was synthesized se...
In the last years, there has been an increasing interest of using cyclooxygenase-2 (COX-2) inhibitor...
There is an autocrine relationship between eicosanoid and cytokine synthesis, with the ratio of pros...
In this study, a panel of inhibitors with a range of selectivities for the two cyclooxygenase isofor...
In this review, the in vitro cellular effects of six nonsteroidal anti-inflammatory drugs (NSAIDs), ...
We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neu...
The two isoforms of cyclooxygenase (COX) catalyze the initial step in the formation of biologically ...
Cyclooxygenase is the key enzyme in the biosynthesis of prostanoids, biologically active substances ...
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid into prostaglandins (PGs), which p...
Primary cultures of fetal hepatocytes expressed cyclooxygen-ase-2 (COX-2) upon stimulation with bact...
Prostaglandins play a key role in mediating the hypothalamo-pituitary-adrenocortical (HPA) responses...
Cyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at ...
For prostaglandin production, the enzyme cyclooxygenase (COX) is required. The two COX isoforms are ...
umbilical vein endothelium produce prostacyclin (PGI2) in response to stimulation by thrombin, ion-o...
The discovery of a second isoform of cyclooxygenase has led to a re-evaluation of the mechanisms und...
Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was synthesized se...
In the last years, there has been an increasing interest of using cyclooxygenase-2 (COX-2) inhibitor...
There is an autocrine relationship between eicosanoid and cytokine synthesis, with the ratio of pros...
In this study, a panel of inhibitors with a range of selectivities for the two cyclooxygenase isofor...
In this review, the in vitro cellular effects of six nonsteroidal anti-inflammatory drugs (NSAIDs), ...
We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neu...
The two isoforms of cyclooxygenase (COX) catalyze the initial step in the formation of biologically ...
Cyclooxygenase is the key enzyme in the biosynthesis of prostanoids, biologically active substances ...
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid into prostaglandins (PGs), which p...
Primary cultures of fetal hepatocytes expressed cyclooxygen-ase-2 (COX-2) upon stimulation with bact...
Prostaglandins play a key role in mediating the hypothalamo-pituitary-adrenocortical (HPA) responses...
Cyclooxygenase (COX), the primary enzyme responsible for the synthesis of prostanoids, exists in at ...
For prostaglandin production, the enzyme cyclooxygenase (COX) is required. The two COX isoforms are ...
umbilical vein endothelium produce prostacyclin (PGI2) in response to stimulation by thrombin, ion-o...
The discovery of a second isoform of cyclooxygenase has led to a re-evaluation of the mechanisms und...
Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was synthesized se...
In the last years, there has been an increasing interest of using cyclooxygenase-2 (COX-2) inhibitor...
There is an autocrine relationship between eicosanoid and cytokine synthesis, with the ratio of pros...