SummaryIn the fission yeast Schizosaccharomyces pombe, interphase microtubules (MTs) position the nucleus [1, 2], which in turn positions the cell-division plane [1, 3]. It is unclear how the spindle orients, with respect to the predetermined division plane, to ensure that the chromosomes are segregated across this plane. It has been proposed that, during prometaphase, the astral MT interaction with the cell cortex aligns the spindle with the cell axis [4] and also participates in a spindle orientation checkpoint (SOC), which delays entry into anaphase as long as the spindle is misaligned [5–7]. Here, we trace the position of the spindle throughout mitosis in a single-cell assay. We find no evidence for the SOC. We show that the spindle is ...
In animal cells, positioning of the mitotic spindle is crucial for defining the plane of cytokinesis...
SummaryThe position of the division plane affects cell shape and size, as well as tissue organizatio...
At the onset of cell division microtubules growing from spindle pole bodies (SPB) interact with each...
In the fission yeast Schizosaccharomyces pombe, interphase microtubules (MTs) position the nucleus [...
Correct spindle alignment requires a cell to detect and interpret its global geometry and to communi...
SummaryIn all eukaryotic cells, correct segregation of the genetic material during cell division req...
International audienceIn all eukaryotes, the alignment of the mitotic spindle with the axis of cell ...
SummaryThe objective of mitosis is to provide a copy of the genome to each progeny of a cell divisio...
Segregating genetic material along the longest axis of the cell ensures that there is a sufficient d...
AbstractThe spindle orientation checkpoint (SOC) in fission yeast has been proposed to delay metapha...
In the budding yeast Saccharomyces cerevisiae, movement of the mitotic spindle to a predetermined cl...
SummaryIn many polarized cells, the accuracy of chromosome segregation depends on the correct positi...
Accurate animal cell division requires precise coordination of changes in the structure of the micro...
SummaryAccurate animal cell division requires precise coordination of changes in the structure of th...
AbstractPrecise positioning of the mitotic spindle is important for specifying the plane of cell div...
In animal cells, positioning of the mitotic spindle is crucial for defining the plane of cytokinesis...
SummaryThe position of the division plane affects cell shape and size, as well as tissue organizatio...
At the onset of cell division microtubules growing from spindle pole bodies (SPB) interact with each...
In the fission yeast Schizosaccharomyces pombe, interphase microtubules (MTs) position the nucleus [...
Correct spindle alignment requires a cell to detect and interpret its global geometry and to communi...
SummaryIn all eukaryotic cells, correct segregation of the genetic material during cell division req...
International audienceIn all eukaryotes, the alignment of the mitotic spindle with the axis of cell ...
SummaryThe objective of mitosis is to provide a copy of the genome to each progeny of a cell divisio...
Segregating genetic material along the longest axis of the cell ensures that there is a sufficient d...
AbstractThe spindle orientation checkpoint (SOC) in fission yeast has been proposed to delay metapha...
In the budding yeast Saccharomyces cerevisiae, movement of the mitotic spindle to a predetermined cl...
SummaryIn many polarized cells, the accuracy of chromosome segregation depends on the correct positi...
Accurate animal cell division requires precise coordination of changes in the structure of the micro...
SummaryAccurate animal cell division requires precise coordination of changes in the structure of th...
AbstractPrecise positioning of the mitotic spindle is important for specifying the plane of cell div...
In animal cells, positioning of the mitotic spindle is crucial for defining the plane of cytokinesis...
SummaryThe position of the division plane affects cell shape and size, as well as tissue organizatio...
At the onset of cell division microtubules growing from spindle pole bodies (SPB) interact with each...