Axial CID and High Pressure Resonance CID in a Miniature Ion Trap Mass Spectrometer Using a Discontinuous Atmospheric Pressure Interface
- Gao, Liang
- Li, Guangtao
- Cooks, R. Graham
DOIAbstract
Axial collision induced dissociation (CID) and high-pressure resonance CID were implemented and compared with normal low-pressure resonance CID in a miniature ion trap mass spectrometer to obtain more complete fragmentation spectra. Axial CID was realized simply by applying a potential to the discontinuous atmospheric pressure interface (DAPI) capillary without performing parent ion isolation before dissociation. High-pressure resonance CID employed a double-introduction pulse scan function, by means of which precursor ions isolated at low-pressure (<10−3 torr) were dissociated at high-pressure (0.1 torr–1 torr) with higher excitation energy, so that tandem MS of isolated precursor ions was achieved and extensive fragmentation was obtained....
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