294 Implementation time of a lipid lowering therapy in patients with dyslipidemia: results of Prysme study

Despite the availability of specific guidelines, the management of dyslipidemia in practice is not optimal.Objective and methodologyPRYSME, a non-interventional multicentre study carried out with 1226 general practitioners, aimed to describe the implementation time of a lipid lowering treatment according to cardiovascular risk level (primary objective) and to identify its determinants. Were eligible patients treated for a dyslipidemia diagnosed less than 2 years ago. Demographic and clinical characteristics and circumstances of diagnosis and treatment initiation were collected.Results3268 patients were included (mean age: 57 years old, males: 64%). 26% were obese and 45% overweight. Only 12% had no cardiovascular risk factors (CRF) at the time of dyslipidemia diagnosis. The most frequent CRF were arterial hypertension (50%), smoking (43%), family history of premature coronary heart disease (28%), HDL-c <0.4g/l (20%) whereas 15% of the patients had a personal history of cardiovascular disease. Dietary programs were initially implemented for 98% of the patients. More than 90% were treated with a statin. The implementation time of the treatment (evaluated according to the biological confirmation of dyslipidemia), according to the initial number of CRF, was as following:0 CRF1 CRF2 CRF≥ 3 CRFSecondary preventionTotal[-3;0] months34.3%28.6%27.1%29.3%49.1%33.1%]0;3] months23.1%26.2%26.4%24.0%21.9%23.9%> 3 months42.6%45.3%46.5%46.8%29.0%43.0%Chi-2 test : P