AbstractPurpose: The aim of this study was to measure the distribution of endogenous plasminogen activators during thrombolysis with an endothelial-conserving model of laminated thrombosis.Methods: Thrombi were raised in the inferior vena cava of rats with thrombin and flow reduction. The thrombi, adjacent vein wall, and distant veins (the superior vena cava) were removed at intervals from 1 hour to 21 days from formation and then cryohomogenized and assayed with specific bioimmunoassays for tissue-type (t-PA) and urokinase-type plasminogen activators (u-PA).Results: The measured t-PA activity of the vein wall around the thrombus was reduced compared with the control inferior vena cava at 4 days. Both the u-PA and t-PA content of the thromb...
AbstractWe demonstrated previously that tissue-type plasminogen activator (t-PA) bound to its specif...
AbstractPurpose: The plasminogen system, which includes tissue type plasminogen activator (tPA), uro...
The vascular endothelium plays an important role in fibrinolysis by producing tissue-type plasminoge...
AbstractPurpose: The aim of this study was to measure the distribution of endogenous plasminogen act...
AbstractObjectivesNeutrophil influx is one of the first events in a formed deep venous thrombosis (D...
AbstractAt least two types of animal plasminogen activating enzymes exist, differing in amino acid s...
Objectives:thrombolytic therapy is frequently used to manage vascular graft thrombosis. However, lon...
The process of acute release of tissue-type plasminogen activator (tPA) is important in locally spee...
The fibrinolytic system has several important functions and one crucial function is the prevention a...
The fibrinolytic system participates in a variety of physiological and pathological processes. It co...
Objective To investigate the reproduction of a new model of thrombosis of inferior vena cava (IVC), ...
The influence of endotoxin-induced elevated plasma levels of the fast-acting inhibitor of plasminoge...
IntroductionThere is an increase in the natural level of urokinase-type plasminogen activator (uPA) ...
Background Our previous studies showed that the direct injection of an adenovirus construct expressi...
ObjectiveEngineered overexpression of tissue plasminogen activator (tPA) in vascular cells has been ...
AbstractWe demonstrated previously that tissue-type plasminogen activator (t-PA) bound to its specif...
AbstractPurpose: The plasminogen system, which includes tissue type plasminogen activator (tPA), uro...
The vascular endothelium plays an important role in fibrinolysis by producing tissue-type plasminoge...
AbstractPurpose: The aim of this study was to measure the distribution of endogenous plasminogen act...
AbstractObjectivesNeutrophil influx is one of the first events in a formed deep venous thrombosis (D...
AbstractAt least two types of animal plasminogen activating enzymes exist, differing in amino acid s...
Objectives:thrombolytic therapy is frequently used to manage vascular graft thrombosis. However, lon...
The process of acute release of tissue-type plasminogen activator (tPA) is important in locally spee...
The fibrinolytic system has several important functions and one crucial function is the prevention a...
The fibrinolytic system participates in a variety of physiological and pathological processes. It co...
Objective To investigate the reproduction of a new model of thrombosis of inferior vena cava (IVC), ...
The influence of endotoxin-induced elevated plasma levels of the fast-acting inhibitor of plasminoge...
IntroductionThere is an increase in the natural level of urokinase-type plasminogen activator (uPA) ...
Background Our previous studies showed that the direct injection of an adenovirus construct expressi...
ObjectiveEngineered overexpression of tissue plasminogen activator (tPA) in vascular cells has been ...
AbstractWe demonstrated previously that tissue-type plasminogen activator (t-PA) bound to its specif...
AbstractPurpose: The plasminogen system, which includes tissue type plasminogen activator (tPA), uro...
The vascular endothelium plays an important role in fibrinolysis by producing tissue-type plasminoge...