TGF-β Regulation by Emilin1: New Links in the Etiology of Hypertension
- Raman, Malavika
- Cobb, Melanie H.
Publication date
March 2006
DOI Publisher
Elsevier Inc. ISSN
0092-8674 Citation count (estimate)
12Abstract
Hypertension is a complex disease influenced by multiple genetic and environmental factors. The TGF-β signaling pathway has a long recognized role in blood pressure homeostasis. In this issue of Cell, Zacchigna et al. (2006) report that the secreted protein Emilin1 is a negative regulator of TGF-β signaling. Emilin1 knockout mice display elevated blood pressure due to increased TGF-β signaling in the vasculature
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