AbstractHeart valve formation is initiated by an epithelial–mesenchymal cell transformation (EMT) of endothelial cells in the atrioventricular (AV) canal. Mesenchymal cells formed from cardiac EMTs are the initial cellular components of the cardiac cushions and progenitors of valvular and septal fibroblasts. It has been shown that transforming growth factor β (TGFβ) mediates EMT in the AV canal, and TGFβ1 and 2 isoforms are expressed in the mouse heart while TGFβ 2 and 3 are expressed in the avian heart. Depletion of TGFβ3 in avian or TGFβ2 in mouse leads to developmental defects of heart tissue. These observations raise questions as to whether multiple TGFβ isoforms participate in valve formation. In this study, we examined the localizatio...
AbstractHeart valve malformations are one of the most common types of birth defects, illustrating th...
AbstractDevelopmental abnormalities in endocardial cushions frequently contribute to congenital hear...
Background—Transforming growth factor-b2 (TGF-b2) is a member of a family of growth factors with the...
AbstractThe formation of endocardial cushions in the atrioventricular (AV) canal of the rudimentary ...
AbstractTransformation of atrioventricular canal endocardium into invasive mesenchyme is a critical ...
AbstractEpithelial–mesenchymal transformation is a critical event in the development of many organ s...
AbstractIn the developing heart, the epicardium is essential for coronary vasculogenesis as it provi...
Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this pr...
Congenital heart defects (CHD) are the most common birth defect, occurring in nearly 1% of all live ...
AbstractValvuloseptal morphogenesis of the primitive heart tube into a four-chambered organ requires...
AbstractEpithelial–mesenchymal transformation (EMT), the process by which epithelial cells are conve...
AbstractTrophic factors secreted both from the endocardium and epicardium regulate appropriate growt...
During heart development endocardial cells within the atrio-ventricular (AV) region undergo TGFbeta-...
TGFβ signalling has long been recognised as having a role in heart development. The central TGFβ typ...
AbstractAn epithelial–mesenchymal cell transformation (EMT) occurs during the development of endocar...
AbstractHeart valve malformations are one of the most common types of birth defects, illustrating th...
AbstractDevelopmental abnormalities in endocardial cushions frequently contribute to congenital hear...
Background—Transforming growth factor-b2 (TGF-b2) is a member of a family of growth factors with the...
AbstractThe formation of endocardial cushions in the atrioventricular (AV) canal of the rudimentary ...
AbstractTransformation of atrioventricular canal endocardium into invasive mesenchyme is a critical ...
AbstractEpithelial–mesenchymal transformation is a critical event in the development of many organ s...
AbstractIn the developing heart, the epicardium is essential for coronary vasculogenesis as it provi...
Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this pr...
Congenital heart defects (CHD) are the most common birth defect, occurring in nearly 1% of all live ...
AbstractValvuloseptal morphogenesis of the primitive heart tube into a four-chambered organ requires...
AbstractEpithelial–mesenchymal transformation (EMT), the process by which epithelial cells are conve...
AbstractTrophic factors secreted both from the endocardium and epicardium regulate appropriate growt...
During heart development endocardial cells within the atrio-ventricular (AV) region undergo TGFbeta-...
TGFβ signalling has long been recognised as having a role in heart development. The central TGFβ typ...
AbstractAn epithelial–mesenchymal cell transformation (EMT) occurs during the development of endocar...
AbstractHeart valve malformations are one of the most common types of birth defects, illustrating th...
AbstractDevelopmental abnormalities in endocardial cushions frequently contribute to congenital hear...
Background—Transforming growth factor-b2 (TGF-b2) is a member of a family of growth factors with the...