AbstractAn original serie of 12- to 22-residue-long peptides was developed, they are only constituted by apolar Leu and charged Lys residues periodically located in the sequence in order to generate ideal highly amphipathic α-helices. By circular dichroism, the peptides are proven to be mainly α-helical in organic and aqueous solvents and in the presence of lipids. The peptides are highly hemolytic, their activity varies according to the peptide length. The 15-, 20-, and 22-residue-long-peptides have LD50 ∼5 × 10−8 M for 107 erythrocytes, i.e. they are 5–10 times more active than melittin, and are indeed several orders of magnitude more active than magainin or mastoparan
Amphipathic helical peptides represent the lipid-binding units of the soluble plasma apolipop...
We have designed de novo and synthesized ten 26-residue D-conformation amphipathic α-helical cationi...
Amphipathic peptides can act as antibiotics due to membrane permeabilization. KL peptides with the r...
AbstractAn original serie of 12- to 22-residue-long peptides was developed, they are only constitute...
AbstractIn a minimalist approach to modeling lytic toxins, amphipathic peptides of LiKj with i=2j co...
A synthetic, 26-residue peptide having a strong helix forming potential in the protonated state was ...
AbstractIn silico structural analyses of sets of α-helical antimicrobial peptides (AMPs) are perform...
A synthetic, 26-residue peptide having a strong helix forming potential in the protonated state was ...
A synthetic, 26-residue peptide having a strong helix forming potential in the protonated state was ...
The δ-toxin is a 26-residue peptide from Staphylococcus aureus with the sequence formyl-MAQDIIS...
The δ-toxin is a 26-residue peptide from Staphylococcus aureus with the sequence formyl-MAQDIIS...
AbstractDesigned to model ideally amphipathic β-sheets, the minimalist linear (KL)mK peptides (m=4–7...
AbstractResidues 1–9 of M(12–26) (GLPALISWIKRKRQQ-NH2), the C-terminal 15-residue segment of melitti...
Antimicrobial peptides (AMPs) that assume an amphipathic \u3b1 helical structure are widespread in n...
SB056 is a novel semi-synthetic antimicrobial peptide with a dimeric dendrimer scaffold. Active agai...
Amphipathic helical peptides represent the lipid-binding units of the soluble plasma apolipop...
We have designed de novo and synthesized ten 26-residue D-conformation amphipathic α-helical cationi...
Amphipathic peptides can act as antibiotics due to membrane permeabilization. KL peptides with the r...
AbstractAn original serie of 12- to 22-residue-long peptides was developed, they are only constitute...
AbstractIn a minimalist approach to modeling lytic toxins, amphipathic peptides of LiKj with i=2j co...
A synthetic, 26-residue peptide having a strong helix forming potential in the protonated state was ...
AbstractIn silico structural analyses of sets of α-helical antimicrobial peptides (AMPs) are perform...
A synthetic, 26-residue peptide having a strong helix forming potential in the protonated state was ...
A synthetic, 26-residue peptide having a strong helix forming potential in the protonated state was ...
The δ-toxin is a 26-residue peptide from Staphylococcus aureus with the sequence formyl-MAQDIIS...
The δ-toxin is a 26-residue peptide from Staphylococcus aureus with the sequence formyl-MAQDIIS...
AbstractDesigned to model ideally amphipathic β-sheets, the minimalist linear (KL)mK peptides (m=4–7...
AbstractResidues 1–9 of M(12–26) (GLPALISWIKRKRQQ-NH2), the C-terminal 15-residue segment of melitti...
Antimicrobial peptides (AMPs) that assume an amphipathic \u3b1 helical structure are widespread in n...
SB056 is a novel semi-synthetic antimicrobial peptide with a dimeric dendrimer scaffold. Active agai...
Amphipathic helical peptides represent the lipid-binding units of the soluble plasma apolipop...
We have designed de novo and synthesized ten 26-residue D-conformation amphipathic α-helical cationi...
Amphipathic peptides can act as antibiotics due to membrane permeabilization. KL peptides with the r...