AbstractAnteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishment of segmental domains of Hox expression. We investigated the mechanism that governs the early expression of Hoxb4 and found that transient signaling from the paraxial mesoderm induces expression in the hindbrain. Induction involves a retinoid pathway requiring retinoic acid receptor (RAR) function within the neural plate. Characterization of a prerhombomeric enhancer from Hoxb4 reveals that a retinoic acid (RA) response element is an essential component of the early neural response to somite (s) signaling and can interpret positional information for setting the anterior boundary of expression. These data suggest a mechanism whereby, during...
AbstractZebrafish hoxb1b is expressed during epiboly in the posterior neural plate, with its anterio...
AbstractRetinoic acid (RA) signaling plays an important role in determining the anterior boundary of...
AbstractThe antero-posterior (AP) and dorso-ventral (DV) patterning of the neural tube is controlled...
AbstractAnteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishm...
SummaryIn vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to t...
AbstractThe developing vertebrate hindbrain consists of segments known as rhombomeres, which express...
We have investigated the mechanisms involved in generating hindbrain motoneurone subtypes, focusing ...
AbstractA prominent region of the vertebrate hindbrain is subdivided along the anterior–posterior ax...
The proper regulation of Hox gene expression during development is crucial for normal patterning to ...
During vertebrate neural development, positional information is largely specified by extracellular m...
It has been suggested that Hox genes play an important part in the patterning of limbs, vertebrae an...
Retinoic acid (RA) generated by Raldh2 in paraxial mesoderm is required for specification of the pos...
AbstractThe vertebrate hindbrain is segmented into an array of rhombomeres (r), but it remains to be...
AbstractThe Hoxa2 gene is an important component of regulatory events during hindbrain segmentation ...
It has been shown by using the quail/chick chimera system that Hox gene expression in the hindbrain ...
AbstractZebrafish hoxb1b is expressed during epiboly in the posterior neural plate, with its anterio...
AbstractRetinoic acid (RA) signaling plays an important role in determining the anterior boundary of...
AbstractThe antero-posterior (AP) and dorso-ventral (DV) patterning of the neural tube is controlled...
AbstractAnteroposterior (AP) patterning in the vertebrate hindbrain is dependent upon the establishm...
SummaryIn vertebrate embryos, retinoic acid (RA) synthesized in the mesoderm by Raldh2 emanates to t...
AbstractThe developing vertebrate hindbrain consists of segments known as rhombomeres, which express...
We have investigated the mechanisms involved in generating hindbrain motoneurone subtypes, focusing ...
AbstractA prominent region of the vertebrate hindbrain is subdivided along the anterior–posterior ax...
The proper regulation of Hox gene expression during development is crucial for normal patterning to ...
During vertebrate neural development, positional information is largely specified by extracellular m...
It has been suggested that Hox genes play an important part in the patterning of limbs, vertebrae an...
Retinoic acid (RA) generated by Raldh2 in paraxial mesoderm is required for specification of the pos...
AbstractThe vertebrate hindbrain is segmented into an array of rhombomeres (r), but it remains to be...
AbstractThe Hoxa2 gene is an important component of regulatory events during hindbrain segmentation ...
It has been shown by using the quail/chick chimera system that Hox gene expression in the hindbrain ...
AbstractZebrafish hoxb1b is expressed during epiboly in the posterior neural plate, with its anterio...
AbstractRetinoic acid (RA) signaling plays an important role in determining the anterior boundary of...
AbstractThe antero-posterior (AP) and dorso-ventral (DV) patterning of the neural tube is controlled...