The inappropriate expansion of self-reactive “bystander” T cells can contribute to autoimmune disease. In this issue of Immunity, Watanabe et al. (2014) demonstrate that the tumor suppressor p53 prevents the cytokine-dependent proliferation of T cells in the absence of cognate antigens
T cells proliferate vigorously following acute depletion of CD4+ Foxp3+ T regulatory cells [natural ...
As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) p...
The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunit...
The inappropriate expansion of self-reactive “bystander” T cells can contribute to autoimmune diseas...
SummaryAntigen specificity is critical in immune response and requires integration of antigen-specif...
ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant se...
Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequen...
Self-tolerance to p53 is a major potential limitation for the activation of the endogenous T-cell re...
The commonly held view of the tumor suppressor p53 as a regulator of cell proliferation, apoptosis a...
SummaryMice deficient in the DNA damage sensor P53 display normal T cell development but eventually ...
Central and peripheral tolerance prevent autoimmunity by deleting the most aggressive CD8(+) T cells...
AbstractPositive selection to self-MHC/peptide complexes has long been viewed as a device for skewin...
The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved i...
It has been shown that self-reactive T cells can be detected in the periphery. In this issue of Immu...
© 2015 Dr. Sarah Anne OverallThe recognition of self-antigen by the T cell receptor (TCR) defines T ...
T cells proliferate vigorously following acute depletion of CD4+ Foxp3+ T regulatory cells [natural ...
As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) p...
The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunit...
The inappropriate expansion of self-reactive “bystander” T cells can contribute to autoimmune diseas...
SummaryAntigen specificity is critical in immune response and requires integration of antigen-specif...
ealthy individuals are known to harbour self-specific T cells against a variety of immunodominant se...
Loss of p53 function contributes to the development of many cancers. While cell-autonomous consequen...
Self-tolerance to p53 is a major potential limitation for the activation of the endogenous T-cell re...
The commonly held view of the tumor suppressor p53 as a regulator of cell proliferation, apoptosis a...
SummaryMice deficient in the DNA damage sensor P53 display normal T cell development but eventually ...
Central and peripheral tolerance prevent autoimmunity by deleting the most aggressive CD8(+) T cells...
AbstractPositive selection to self-MHC/peptide complexes has long been viewed as a device for skewin...
The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved i...
It has been shown that self-reactive T cells can be detected in the periphery. In this issue of Immu...
© 2015 Dr. Sarah Anne OverallThe recognition of self-antigen by the T cell receptor (TCR) defines T ...
T cells proliferate vigorously following acute depletion of CD4+ Foxp3+ T regulatory cells [natural ...
As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) p...
The immune system has evolved to allow robust responses against pathogens while avoiding autoimmunit...
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