729-4 Left Ventricular Hypertrophy and the Deletion-Insertion Polymorphism of the Angiotensin Converting Enzyme Gene

A recent case-control study reported a higher odds of left ventricular hypertrophy (LVH) on ECG among subjects homozygous for the angiotensin converting enzyme (ACE) gene deletion (D) polymorphism. We examined the relations of the ACE deletion-insertion (D-I) polymorphism to echocardiographically defined LVH in 2472 subjects from the Framingham Heart Study (mean age 48.7 range 20 to 86). LVH (defined as LVmass/height>102g/m in women and >143glm in men) was present in 15% of the study sample. Logistic regression analyses revealed no relation between the DD genotype and LVH. Association analyses also revealed no differences in mean levels of LV mass among the three genotypes. These results did not differ after adjustment for age, sex and obesity.No LVH (n=2097)LVH (n=375)Odds Ratio (II reference)95% CIDD29.3%31.2%0.940.69–1.28DI51.5%46.9%0.800.6D–1.07II19.2%21.9%1.00-Analysis of 31 sib-pairs with LVH also revealed no association (P=0.53) with the D-I polymorphism.We conclude that in the population-based sample of the Framingham Heart Study, there is no association between the ACE D-I polymorphism and level of LV mass or prevalence of LVH