AbstractThe peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form highly stable but soluble β-rich self-assembly-like structures similar to those formed by native amyloid-forming peptides. However, unlike amyloids that predominantly form insoluble aggregates, PSAMs are highly water-soluble. Here, we characterize the conformations of these soluble β-sheet-rich assemblies. We simulate PSAMs with different-sized β-sheets in the presence and absence of end-capping proteins using all-atom explicit-solvent molecular dynamics, comparing the structural stability, conformational dynamics, and association force. Structural and free-energy comparisons among β-sheets with different numbers of layers and sequences indicate ...
Several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases a...
The self-assembly of abnormally folded proteins into amyloid fibrils is a hallmark of many debilitat...
Transformation of proteins and peptides to fibrillar aggregates rich in β sheets underlies many dise...
AbstractThe peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form high...
The peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form highly stabl...
AbstractSeveral neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseas...
Several neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases are a...
AbstractThe free energy landscape for folding of the Alzheimer’s amyloid-β(25–35) peptide is explore...
AbstractThe 16–22 amino-acid fragment of the β-amyloid peptide associated with the Alzheimer’s disea...
The formation of well-defined filamentous amyloid structures involves a polydisperse collection of o...
The aggregation modes of hexapeptide fragments of Tau, Insulin and Aβ peptide (VQIVYK, MVGGVV and LY...
AbstractWe investigated the supramolecular structure and continuum mechanical properties of a β-shee...
AbstractA seven amino acid yeast prion sup-35 fragment (GNNQQNY) forms amyloid fibrils. The availabi...
peer-reviewedAmyloid aggregates have been linked to diseases, including neurodegenerative ones suc...
AbstractUnderstanding the structural and energetic requirements of non-fibrillar oligomer formation ...
Several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases a...
The self-assembly of abnormally folded proteins into amyloid fibrils is a hallmark of many debilitat...
Transformation of proteins and peptides to fibrillar aggregates rich in β sheets underlies many dise...
AbstractThe peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form high...
The peptide self-assembly mimic (PSAM) from the outer surface protein A (OspA) can form highly stabl...
AbstractSeveral neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseas...
Several neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases are a...
AbstractThe free energy landscape for folding of the Alzheimer’s amyloid-β(25–35) peptide is explore...
AbstractThe 16–22 amino-acid fragment of the β-amyloid peptide associated with the Alzheimer’s disea...
The formation of well-defined filamentous amyloid structures involves a polydisperse collection of o...
The aggregation modes of hexapeptide fragments of Tau, Insulin and Aβ peptide (VQIVYK, MVGGVV and LY...
AbstractWe investigated the supramolecular structure and continuum mechanical properties of a β-shee...
AbstractA seven amino acid yeast prion sup-35 fragment (GNNQQNY) forms amyloid fibrils. The availabi...
peer-reviewedAmyloid aggregates have been linked to diseases, including neurodegenerative ones suc...
AbstractUnderstanding the structural and energetic requirements of non-fibrillar oligomer formation ...
Several neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's diseases a...
The self-assembly of abnormally folded proteins into amyloid fibrils is a hallmark of many debilitat...
Transformation of proteins and peptides to fibrillar aggregates rich in β sheets underlies many dise...