SummaryDDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in diverse cellular functions, including nuclear excision repair, regulation of the cell cycle, and DNA replication. To investigate its physiological significance, we generated mice with null and floxed alleles of the DDB1 gene. Here we report that null mutation of DDB1 caused early embryonic lethality, while conditional inactivation of the gene in brain and lens led to neuronal and lens degeneration, brain hemorrhages, and neonatal death. These defects stemmed from a selective elimination of nearly all proliferating neuronal progenitor cells and lens epithelial cells by apoptosis. The cell death was preceded by aberrant accumulation of cell cycle...
Damaged DNA-binding protein, DDB, is a heterodimer of p127 and p48 with a high specificity for bindi...
textabstractNucleotide excision repair (NER) is the principal pathway for counteracting cytotoxic an...
<p>(A) Western blot for some substrates of DDB1-Cul4A ubiquitin ligase using lysates of hepatocytes ...
SummaryDDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in di...
<div><p>DNA damage-binding protein 1 (DDB1) is a large subunit of the heterodimeric DDB complex that...
DNA damage-binding protein 1 (DDB1) is a large subunit of the heterodimeric DDB complex that recogni...
The xeroderma pigmentosum group E gene product DDB2, a protein involved in nucleotide excision repai...
The human UV-damaged DNA-binding protein Ddb1 associates with cullin 4 ubiquitin ligases implicated ...
<p>Ddb1, as a component of the CUL4-DDB1 ubiquitin ligase complex, may control, among other targets ...
Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and ...
In mammalian nucleotide excision repair, the DDB1-DDB2 complex recognizes UV-induced DNA photolesion...
UV-damaged DNA-binding protein (UV-DDB) is essential for global genome repair (GGR) of UV-induced cy...
The DNA replication licensing factor Cdt1 is degraded by the ubiquitin-proteasome pathway during S p...
Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in ...
DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of ...
Damaged DNA-binding protein, DDB, is a heterodimer of p127 and p48 with a high specificity for bindi...
textabstractNucleotide excision repair (NER) is the principal pathway for counteracting cytotoxic an...
<p>(A) Western blot for some substrates of DDB1-Cul4A ubiquitin ligase using lysates of hepatocytes ...
SummaryDDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitination in di...
<div><p>DNA damage-binding protein 1 (DDB1) is a large subunit of the heterodimeric DDB complex that...
DNA damage-binding protein 1 (DDB1) is a large subunit of the heterodimeric DDB complex that recogni...
The xeroderma pigmentosum group E gene product DDB2, a protein involved in nucleotide excision repai...
The human UV-damaged DNA-binding protein Ddb1 associates with cullin 4 ubiquitin ligases implicated ...
<p>Ddb1, as a component of the CUL4-DDB1 ubiquitin ligase complex, may control, among other targets ...
Little is known on post-transcriptional regulation of adult and embryonic stem cell maintenance and ...
In mammalian nucleotide excision repair, the DDB1-DDB2 complex recognizes UV-induced DNA photolesion...
UV-damaged DNA-binding protein (UV-DDB) is essential for global genome repair (GGR) of UV-induced cy...
The DNA replication licensing factor Cdt1 is degraded by the ubiquitin-proteasome pathway during S p...
Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in ...
DDB2, a gene mutated in XPE patients, is involved in global genomic repair especially the repair of ...
Damaged DNA-binding protein, DDB, is a heterodimer of p127 and p48 with a high specificity for bindi...
textabstractNucleotide excision repair (NER) is the principal pathway for counteracting cytotoxic an...
<p>(A) Western blot for some substrates of DDB1-Cul4A ubiquitin ligase using lysates of hepatocytes ...