SummaryThe association rate constants (ka) of proteins with other proteins or other macromolecular targets are a fundamental biophysical property. Observed rate constants span over ten orders of magnitude, from 1 to 1010 M−1s−1. Protein association can be rate limited either by the diffusional approach of the subunits to form a transient complex, with near-native separation and orientation but without short-range native interactions, or by the subsequent conformational rearrangement to form the native complex. Our transient-complex theory showed promise in predicting ka in the diffusion-limited regime. Here, we develop it into a web server called TransComp (http://pipe.sc.fsu.edu/transcomp/) and report on the server's accuracy and robustnes...
AbstractTheory and computation have long been used to rationalize the experimental association rate ...
Protein-protein interactions are central to understanding how cells carry out their wide array of f...
A unified model is presented for protein-protein association processes that are under the influences...
SummaryThe association rate constants (ka) of proteins with other proteins or other macromolecular t...
SummaryWe recently developed a theory for the rates of protein-protein association. The theory is ba...
Actin is an abundant protein that constitutes a main component of the eukaryotic cytoskeleton. Its p...
The rate of protein association places an upper limit on the response time due to protein interactio...
Electrostatic interactions are known experimentally to enhance the rate of protein-protein associati...
Abstract Background Proteins form various complexes to carry out their versatile functions in cells....
Presented on November 9, 2011 from 3:00 pm to 4:00 pm In Howey building room L5.Runtime: 54:58 minut...
<div><p>The prediction of protein-protein kinetic rate constants provides a fundamental test of our ...
AbstractFormation of a stereospecific protein complex is favored by specific interactions between tw...
The prediction of protein-protein kinetic rate constants provides a fundamental test of our understa...
Elucidating kinetic processes of protein protein interactions (PPI) helps to understand how basic bu...
Electrostatic interactions are known experimentally to enhance the rate of protein-protein associati...
AbstractTheory and computation have long been used to rationalize the experimental association rate ...
Protein-protein interactions are central to understanding how cells carry out their wide array of f...
A unified model is presented for protein-protein association processes that are under the influences...
SummaryThe association rate constants (ka) of proteins with other proteins or other macromolecular t...
SummaryWe recently developed a theory for the rates of protein-protein association. The theory is ba...
Actin is an abundant protein that constitutes a main component of the eukaryotic cytoskeleton. Its p...
The rate of protein association places an upper limit on the response time due to protein interactio...
Electrostatic interactions are known experimentally to enhance the rate of protein-protein associati...
Abstract Background Proteins form various complexes to carry out their versatile functions in cells....
Presented on November 9, 2011 from 3:00 pm to 4:00 pm In Howey building room L5.Runtime: 54:58 minut...
<div><p>The prediction of protein-protein kinetic rate constants provides a fundamental test of our ...
AbstractFormation of a stereospecific protein complex is favored by specific interactions between tw...
The prediction of protein-protein kinetic rate constants provides a fundamental test of our understa...
Elucidating kinetic processes of protein protein interactions (PPI) helps to understand how basic bu...
Electrostatic interactions are known experimentally to enhance the rate of protein-protein associati...
AbstractTheory and computation have long been used to rationalize the experimental association rate ...
Protein-protein interactions are central to understanding how cells carry out their wide array of f...
A unified model is presented for protein-protein association processes that are under the influences...