Long-Term Benefit of Early Pre-Reperfusion Metoprolol Administration in Patients With Acute Myocardial Infarction Results From the METOCARD-CNIC Trial (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction)
- Pizarro, Gonzalo
- Fernández-Friera, Leticia
- Fuster, Valentin
- Fernández-Jiménez, Rodrigo
- García-Ruiz, José M.
- García-Álvarez, Ana
- Mateos, Alonso
- Barreiro, María V.
- Escalera, Noemí
- Rodriguez, Maite D.
- de Miguel, Antonio
- García-Lunar, Inés
- Parra-Fuertes, Juan J.
- Sánchez-González, Javier
- Pardillos, Luis
- Nieto, Beatriz
- Jiménez, Adriana
- Abejón, Raquel
- Bastante, Teresa
- Martínez de Vega, Vicente
- Cabrera, José A.
- López-Melgar, Beatriz
- Guzman, Gabriela
- García-Prieto, Jaime
- Mirelis, Jesús G.
- Zamorano, José Luis
- Albarrán, Agustín
- Goicolea, Javier
- Escaned, Javier
- Pocock, Stuart
- Iñiguez, Andrés
- Fernández-Ortiz, Antonio
- Sánchez-Brunete, Vicente
- Macaya, Carlos
- Ibanez, Borja
DOIAbstract
ObjectivesThe goal of this trial was to study the long-term effects of intravenous (IV) metoprolol administration before reperfusion on left ventricular (LV) function and clinical events.BackgroundEarly IV metoprolol during ST-segment elevation myocardial infarction (STEMI) has been shown to reduce infarct size when used in conjunction with primary percutaneous coronary intervention (pPCI).MethodsThe METOCARD-CNIC (Effect of Metoprolol in Cardioprotection During an Acute Myocardial Infarction) trial recruited 270 patients with Killip class ≤II anterior STEMI presenting early after symptom onset (<6 h) and randomized them to pre-reperfusion IV metoprolol or control group. Long-term magnetic resonance imaging (MRI) was performed on 202 patien...
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