AbstractConnexin40 (Cx40) is the main connexin expressed in the murine atria and ventricular conduction system. We assess here the developmental role of Cx40 in atrial conduction of the mouse. Cx40 deficiency significantly prolonged activation times in embryonic day 10.5, 12.5 and 14.5 atria during spontaneous activation; the severity decreased with increasing age. In a majority of Cx40 deficient mice the impulse originated from an ectopic focus in the right atrial appendage; in such a case the activation time was even longer due to prolonged activation. Cx40 has thus an important physiological role in the developing atria
Aims Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to...
Co-expressed connexins (Cxs) can co-assemble to form gap junction channels (GJCs) of mixed Cxs compo...
AbstractBackground: Connexins are the protein subunits of intercellular gap junction channels. In ma...
AbstractIntercellular channels of gap junctions are formed in vertebrates by the protein family of c...
Developmental mechanisms of arrhythmias - role of connexins in arrhythmogenesis MUDr.Jiří Beneš Abst...
Atrial tissue expresses both connexin 40 (Cx40) and 43 (Cx43) proteins. To assess the relative roles...
Gap junction channels (GJC) provide the direct electrical and chemical cell-to-cell communication. T...
The rhythmic and coordinated propagation cardiac of the action potential is ensured by gap junction ...
Background—Myocardial conduction depends on intercellular transfer of currrent at gap junctions. Atr...
Connexin (Cx)40 and Cx45 are the major protein subunits of gap junction channels in the conduction s...
Abstract—Gap junctions are intercellular channels formed by oligomerization of a protein called conn...
Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction.Alcole...
AbstractActivation of cardiac muscle is mediated by the His–Purkinje system, a discrete pathway cont...
AbstractGene ablation studies in mice have revealed roles for gap junction proteins (connexins) in h...
Aims This study aimed at characterizing expression and the functional role of the Gjb6 gene, encodin...
Aims Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to...
Co-expressed connexins (Cxs) can co-assemble to form gap junction channels (GJCs) of mixed Cxs compo...
AbstractBackground: Connexins are the protein subunits of intercellular gap junction channels. In ma...
AbstractIntercellular channels of gap junctions are formed in vertebrates by the protein family of c...
Developmental mechanisms of arrhythmias - role of connexins in arrhythmogenesis MUDr.Jiří Beneš Abst...
Atrial tissue expresses both connexin 40 (Cx40) and 43 (Cx43) proteins. To assess the relative roles...
Gap junction channels (GJC) provide the direct electrical and chemical cell-to-cell communication. T...
The rhythmic and coordinated propagation cardiac of the action potential is ensured by gap junction ...
Background—Myocardial conduction depends on intercellular transfer of currrent at gap junctions. Atr...
Connexin (Cx)40 and Cx45 are the major protein subunits of gap junction channels in the conduction s...
Abstract—Gap junctions are intercellular channels formed by oligomerization of a protein called conn...
Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction.Alcole...
AbstractActivation of cardiac muscle is mediated by the His–Purkinje system, a discrete pathway cont...
AbstractGene ablation studies in mice have revealed roles for gap junction proteins (connexins) in h...
Aims This study aimed at characterizing expression and the functional role of the Gjb6 gene, encodin...
Aims Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to...
Co-expressed connexins (Cxs) can co-assemble to form gap junction channels (GJCs) of mixed Cxs compo...
AbstractBackground: Connexins are the protein subunits of intercellular gap junction channels. In ma...